Natural Human Factor V protein (ab62414)

Overview

Description

  • NatureNatural
  • SourceNative
  • Amino Acid Sequence
    • SpeciesHuman

Specifications

Our Abpromise guarantee covers the use of ab62414 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

    Functional Studies

  • FormLiquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 50% Glycerol, 50% H2O

General Info

  • Alternative names
    • Activated protein C cofactor
    • APC cofactor
    • Coagulation factor V
    • coagulation factor V (proaccelerin, labile factor)
    • coagulation factor V jinjiang A2 domain
    • Coagulation factor V light chain
    • F5
    • FA5_HUMAN
    • Factor V Leiden
    • FactorV
    • FVL
    • Labile factor
    • PCCF
    • Proaccelerin
    • proaccelerin, labile factor
    • Protein C cofactor
    • RPRGL1
    • THPH2
    see all
  • FunctionCentral regulator of hemostasis. It serves as a critical cofactor for the prothrombinase activity of factor Xa that results in the activation of prothrombin to thrombin.
  • Tissue specificityPlasma.
  • Involvement in diseaseFactor V deficiency
    Thrombophilia due to activated protein C resistance
    Budd-Chiari syndrome
    Ischemic stroke
    Pregnancy loss, recurrent, 1
  • Sequence similaritiesBelongs to the multicopper oxidase family.
    Contains 3 F5/8 type A domains.
    Contains 2 F5/8 type C domains.
    Contains 6 plastocyanin-like domains.
  • DomainDomain B contains 35 x 9 AA tandem repeats, and 2 x 17 AA repeats.
  • Post-translational
    modifications
    Thrombin activates factor V proteolytically to the active cofactor, factor Va (formation of a heavy chain at the N-terminus and a light chain at the C-terminus).
    Sulfation is required for efficient thrombin cleavage and activation and for full procoagulant activity.
    Activated protein C inactivates factor V and factor Va by proteolytic degradation.
    Phosphorylation sites are present in the extracellular medium.
  • Cellular localizationSecreted.
  • Information by UniProt

References for Natural Human Factor V protein (ab62414)

ab62414 has not yet been referenced specifically in any publications.

Product Wall

Thank you very much for your interest in our proteins. Unfortunately we do currently only have the human and bovine factor V in our catalogue. These are the ab62414 (human) and the ab62236 (bovine). Please let me know if you would like to receive more ...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"