Native Human Factor XIa protein (ab62411)
Key features and details
- Expression system: Native
- Purity: > 95% Immunogen affinity purified
- Suitable for: SDS-PAGE, Functional Studies
Description
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Product name
Native Human Factor XIa protein
See all Factor XIa proteins and peptides -
Purity
> 95 % Immunogen affinity purified.
Factor XIa was prepared by activating purified factor XI with factor XIIa. Following activation, the mixture is passed over a column of immobilized anti-factor XII to remove the factor XIIa, and further purified on heparin-Sepharose. Purity is assessed by SDS PAGE analysis. -
Expression system
Native -
Protein length
Full length protein -
Animal free
No -
Nature
Native -
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Species
Human
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Specifications
Our Abpromise guarantee covers the use of ab62411 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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Applications
SDS-PAGE
Functional Studies
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Form
Liquid -
Concentration information loading...
Preparation and Storage
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Stability and Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Constituents: 50% Glycerol, 50% Water
General Info
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Alternative names
- coagulation factor XI
- Coagulation factor XIa light chain
- F11
see all -
Function
Factor XI triggers the middle phase of the intrinsic pathway of blood coagulation by activating factor IX. -
Tissue specificity
Isoform 2 is produced by platelets and megakaryocytes but absent from other blood cells. -
Involvement in disease
Defects in F11 are the cause of factor XI deficiency (FA11D) [MIM:612416]; also known as plasma thromboplastin antecedent deficiency or Rosenthal syndrome. It is a hemorrhagic disease characterized by reduced levels and activity of factor XI resulting in moderate bleeding symptoms, usually occurring after trauma or surgery. Patients usually do not present spontaneous bleeding but women can present with menorrhagia. Hemorrhages are usually moderate. -
Sequence similarities
Belongs to the peptidase S1 family. Plasma kallikrein subfamily.
Contains 4 apple domains.
Contains 1 peptidase S1 domain. -
Post-translational
modificationsActivated by factor XIIa (or XII), which cleaves each polypeptide after Arg-387 into the light chain, which contains the active site, and the heavy chain, which associates with high molecular weight (HMW) kininogen. -
Cellular localization
Secreted. - Information by UniProt
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
Datasheets and documents
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SDS download
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Datasheet download
References (0)
ab62411 has not yet been referenced specifically in any publications.