Natural Human Factor XIIIa protein (ab62412)

Overview

  • Product nameNatural Human Factor XIIIa protein
  • Protein lengthFull length protein

Description

  • NatureNatural
  • SourceNative
  • Amino Acid Sequence
    • SpeciesHuman

Specifications

Our Abpromise guarantee covers the use of ab62412 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • FormLiquid
  • Additional notes

    Enzymatic FXIIIa is composed of A2'B2. Ab62412 is the active, enzymatic tetrameric form (A2'B2) in absence of calcium ions. In contrast to the inactive tetrameric FXIII (A2B2), ab62412 has been activated by thrombin.

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 50% Glycerol, 0.5mM EDTA

General Info

  • Alternative names
    • bA525O21.1 (coagulation factor XIII, A1 polypeptide)
    • Coagulation factor XIII A chain
    • Coagulation factor XIII A1 polypeptide
    • Coagulation factor XIII A1 subunit
    • Coagulation factor XIII, A polypeptide
    • Coagulation factor XIIIa
    • F13A
    • F13A_HUMAN
    • F13a1
    • Factor XIIIA
    • Fibrin stabilizing factor, A subunit
    • Fibrinoligase
    • FSF, A subunit
    • Protein glutamine gamma glutamyltransferase A chain
    • Protein-glutamine gamma-glutamyltransferase A chain
    • TGase
    • Transglutaminase A chain
    • Transglutaminase. plasma
    see all
  • FunctionFactor XIII is activated by thrombin and calcium ion to a transglutaminase that catalyzes the formation of gamma-glutamyl-epsilon-lysine cross-links between fibrin chains, thus stabilizing the fibrin clot. Also cross-link alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin.
  • Involvement in diseaseDefects in F13A1 are the cause of factor XIII subunit A deficiency (FA13AD) [MIM:613225]. FA13AD is an autosomal recessive disorder characterized by a life-long bleeding tendency, impaired wound healing and spontaneous abortion in affected women.
  • Sequence similaritiesBelongs to the transglutaminase superfamily. Transglutaminase family.
  • Post-translational
    modifications
    The activation peptide is released by thrombin.
  • Cellular localizationCytoplasm. Secreted. Secreted into the blood plasma. Cytoplasmic in most tissues, but also secreted in the blood plasma.
  • Information by UniProt

Natural Human Factor XIIIa protein images

  • Lane 1 : Non-reduced Factor XIIIa protein (ab62412) at 1 µg
    Lane 2 : Molecular weight standard
    Lane 3 : Reduced Factor XIIIa protein (ab62412) at 1 µg
    Notes: In the non-reduced sample the A chain shifts down toward the B chain following activation.

References for Natural Human Factor XIIIa protein (ab62412)

ab62412 has not yet been referenced specifically in any publications.

Product Wall

Vielen Dank für Ihre Antwort. Leider haben wir aktuell kein aufgereinigtes A chain des Factors XIIIa oder Factors XIII in unserem Katalog. Ich habe auch das Labor die den ab62412 produziert angefragt, ob ein aufgereinigtes A chain erhältich sei,...

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Thank you for your inquiry. Indeed, the protein ab62412, Factor XIIIa, is not recombinantly expressed, but the human purified protein. As expected therefore, the molecular weight is around 70kD. Please see the SDS-Page image in the atta...

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Thank you for contacting us. Activity of the proteins was assayed with a commercially available kit, as described below. (We do not offer the kit in our catalogue). The protein has not, to our knowledge, been used in any kind of functional assa...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"