Natural human Gamma Thrombin protein (ab81592)

Overview

  • Product nameNatural human Gamma Thrombin protein
  • Protein lengthFull length protein

Description

  • NatureNatural
  • SourceNative
  • Amino Acid Sequence
    • SpeciesHuman
    • Amino acids328 to 622

Specifications

Our Abpromise guarantee covers the use of ab81592 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Biological activity<1% Thrombin activity. Specific activity is determined by Fibrinogen clotting assay relative to NIH standard thrombin. 1 NIH Unit = 1.15 IS Units
  • Applications

    Functional Studies

    SDS-PAGE

  • Purity> 95 % SDS-PAGE.

  • FormLiquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 6.50
    Constituents: 0.1% Polyethylene glycol, 1.64% Sodium phosphate

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

General Info

  • Alternative names
    • Activation peptide fragment 1
    • Activation peptide fragment 2
    • Cf 2
    • Cf2
    • Coagulation factor II
    • Coagulation factor II (thrombin)
    • FII
    • Prepro coagulation factor II
    • Prothrombin
    • Prothrombin B chain
    • PT
    • RP23-176N9.4
    • RPRGL2
    • Serine protease
    • THPH1
    • Thrombin heavy chain
    • Thrombin light chain
    see all
  • RelevanceThrombin is an active enzyme in the earliest steps of the blood clot formation, generated from its circulating inactive precursor prothrombin. Thrombin is a glycoprotein formed by two peptides chains of 36 and 259 amino acids linked by disulfure bonds. Three important sites have been identified on the surface of the enzyme: The catalytic site that confers to the molecule its serine protease activity, the exosite one responsible for the binding of the substrate (fibrinogen or thrombin receptor) and the exosite two responsible for the binding of antithrombin III and inactivation of thrombin. Gamma Thrombin is a proteolyzed form of Alpha Thrombin. Gamma Thrombin consists of four chains (A, B1, B5, B4) with a disulfide link between the A peptide and the B5 peptide.
  • Cellular localizationSecreted, extracellular space.

References for Natural human Gamma Thrombin protein (ab81592)

ab81592 has not yet been referenced specifically in any publications.

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