Natural Human Haptoglobin protein (ab77872)



  • Nature
  • Source
  • Amino Acid Sequence
    • Species


Our Abpromise guarantee covers the use of ab77872 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications


    Sandwich ELISA

  • Purity
    > 95 % SDS-PAGE.
    >95% pure (SDS-PAGE): polymorphic form (mixture of 1-1, 2-1, and/or 2-2)
  • Form
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

    Deionized water.

  • Reconstitution
    Reconstitute using deionized water.

General Info

  • Alternative names
    • Binding peptide
    • BP
    • Haptoglobin alpha chain
    • Haptoglobin alpha(1S) beta
    • Haptoglobin alpha(2FS) beta
    • Haptoglobin beta chain
    • Haptoglobin, alpha polypeptide
    • Haptoglobin, beta polypeptide
    • HP
    • HP2 ALPHA2
    • HP2ALPHA2
    • HPA1S
    • HPT
    • MGC111141
    • Zonulin
    see all
  • Function
    As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage. Haptoglobin also acts as an Antimicrobial; Antioxidant, has antibacterial activity and plays a role in modulating many aspects of the acute phase response. Hemoglobin/haptoglobin complexes are rapidely cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation pathway.
    Uncleaved haptoglogin, also known as zonulin, plays a role in intestinal permeability, allowing intercellular tight junction disassembly, and controlling the equilibrium between tolerance and immunity to non-self antigens.
  • Tissue specificity
    Expressed by the liver and secreted in plasma.
  • Involvement in disease
  • Sequence similarities
    Belongs to the peptidase S1 family.
    Contains 1 peptidase S1 domain.
    Contains 2 Sushi (CCP/SCR) domains.
  • Cellular localization
  • Information by UniProt

Natural Human Haptoglobin protein images

References for Natural Human Haptoglobin protein (ab77872)

ab77872 has not yet been referenced specifically in any publications.

Product Wall

Thank you for your reply.

I just checked our current stock of these proteins and they should both arrive lyophilized. For ab90924, the concentration indicated on the printed datasheet (4.76 mg/mL) will reflect the volume from which the protei...

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Thank you for contacting us.

These proteins are provided in lyophilized form and as such, the concentrations will be reconstitution dependent. I hope this helps, please let me know if you need any additional information or assistance.

Thank you for your recent telephone enquiry.
I can confirm the following information regarding our haptoglobin proteins:

ab77872 Haptoglobin protein
This protein is purified from a mix of donors and so contains all 3 forms.

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Thank you for your explanation and clarification.

I can confirm and reassure you that ab77872: Haptoglobin protein does not contain any buffer components. The haptoglobinwas in water before lyophilization.

I hope this information wi...

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Thank you for your enquiry and your interest in our products.

You are absolutely correct. I can confirm that this product is sold in lyophilised form; it needs to be reconstituted in deionized water.

If you need any further assistan...

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I understand the difficulty that you are having, finding a standard for your experiments. Though the previous lot was a suitable standard, I think the product in general is not, since it is not validated for consistency among lots with regards to sugar...

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I am sorry to deliver the report I received from our supplier: "Catalog ab77872 Purified Human Haptoglobin is not tested in our laboratory for the distribution of sugar groups. (The two lots in question) are 2 different purification events using th...

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