Natural Human Haptoglobin protein (ab90924)



  • NatureNatural
  • SourceNative
  • Amino Acid Sequence
    • SpeciesHuman


Our Abpromise guarantee covers the use of ab90924 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications


  • Purity> 95 % SDS-PAGE.

  • FormLyophilised
  • Additional notesProtein Determination: Extinction Coefficient (E) 0.1% at 280nm, 1cm pathway = 1.20. Prepared from plasma shown to be non reactive for HBsAg, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA approved tests.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at -20ºC.

    De-ionized H2O

General Info

  • Alternative names
    • Binding peptide
    • BP
    • Haptoglobin alpha chain
    • Haptoglobin alpha(1S) beta
    • Haptoglobin alpha(2FS) beta
    • Haptoglobin beta chain
    • Haptoglobin, alpha polypeptide
    • Haptoglobin, beta polypeptide
    • HP
    • HP2 ALPHA2
    • HP2ALPHA2
    • HPA1S
    • HPT
    • MGC111141
    • Zonulin
    see all
  • FunctionAs a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage. Haptoglobin also acts as an Antimicrobial; Antioxidant, has antibacterial activity and plays a role in modulating many aspects of the acute phase response. Hemoglobin/haptoglobin complexes are rapidely cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation pathway.
    Uncleaved haptoglogin, also known as zonulin, plays a role in intestinal permeability, allowing intercellular tight junction disassembly, and controlling the equilibrium between tolerance and immunity to non-self antigens.
  • Tissue specificityExpressed by the liver and secreted in plasma.
  • Involvement in diseaseAnhaptoglobinemia
  • Sequence similaritiesBelongs to the peptidase S1 family.
    Contains 1 peptidase S1 domain.
    Contains 2 Sushi (CCP/SCR) domains.
  • Cellular localizationSecreted.
  • Information by UniProt

Natural Human Haptoglobin protein images

  • SDS-PAGE analysis of ab90924: 4-12% Bis-Tris-HCl NuPAGE gel
    Lane 1: Haptoglobin - 5 µg (reduced/ heated)
    Lane 2: Haptoglobin - 10 µg (reduced/ heated)
    Lane 3: Haptoglobin - 20 µg (reduced/ heated)
    Lane 4: Molecular weight markers
    Lane 5: Haptoglobin - 5 µg (non-reduced/ no heat)
    Lane 6: Haptoglobin - 10 µg (non-reduced/ no heat)
    Lane 7: Haptoglobin - 20 µg (non-reduced/ no heat)

References for Natural Human Haptoglobin protein (ab90924)

ab90924 has not yet been referenced specifically in any publications.

Product Wall

Thank you for your reply.

I just checked our current stock of these proteins and they should both arrive lyophilized. For ab90924, the concentration indicated on the printed datasheet (4.76 mg/mL) will reflect the volume from which the protei...

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Thank you for contacting us.

These proteins are provided in lyophilized form and as such, the concentrations will be reconstitution dependent. I hope this helps, please let me know if you need any additional information or assistance.

Thank you for your recent telephone enquiry.
I can confirm the following information regarding our haptoglobin proteins:

ab77872 Haptoglobin protein
This protein is purified from a mix of donors and so contains all 3 forms.

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