The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Additional notesConcentartion varies from lot to lot but is between 5-10mg/ml
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Preparation and Storage
Stability and Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Constituents: 50% Glycerol
Heparin cofactor 2
Heparin cofactor II
Protease inhibitor leuserpin 2
Protease inhibitor leuserpin-2
serine (or cysteine) proteinase inhibitor, clade D (heparin cofactor), member 1
serpin peptidase inhibitor, clade D (heparin cofactor), member 1
FunctionThrombin inhibitor activated by the glycosaminoglycans, heparin or dermatan sulfate. In the presence of the latter, HC-II becomes the predominant thrombin inhibitor in place of antithrombin III (AT-III). Also inhibits chymotrypsin, but in a glycosaminoglycan-independent manner. Peptides at the N-terminal of HC-II have chemotactic activity for both monocytes and neutrophils.
Tissue specificityExpressed predominantly in liver. Also present in plasma.
Involvement in diseaseThrombophilia due to heparin cofactor 2 deficiency
Sequence similaritiesBelongs to the serpin family.
DomainThe N-terminal acidic repeat region mediates, in part, the glycosaminoglycan-accelerated thrombin inhibition.
Post-translational modificationsPhosphorylation sites are present in the extracellular medium.