Native Human IgA1 protein (ab91020)
Key features and details
- Expression system: Native
- Purity: > 95% SDS-PAGE
- Suitable for: SDS-PAGE
Description
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Product name
Native Human IgA1 protein -
Biological activity
No reaction by IEP to IgA2 antiserum. -
Purity
> 95 % SDS-PAGE. -
Expression system
Native -
Protein length
Full length protein -
Animal free
No -
Nature
Native -
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Species
Human -
Predicted molecular weight
160 kDa
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Specifications
Our Abpromise guarantee covers the use of ab91020 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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Applications
SDS-PAGE
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Form
Liquid -
Additional notes
Protein Determination: Extinction Coefficient (E) 0.1% at 280nm, 1cm pathway = 1.32. Prepared from plasma shown to be non reactive for HBsAg, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA approved tests.No reaction by IEP to IgA2 antiserum. -
Concentration information loading...
Preparation and Storage
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Stability and Storage
Shipped on Dry Ice. Store at -20°C.
pH: 7.40
Preservative: 0.05% Sodium azide
Constituents: 0.0268% PBS, 0.87% Sodium chloride
General Info
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Alternative names
- Ig alpha 1 chain C region
- IGHA1
- immunoglobulin heavy constant alpha 1
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Relevance
Ig alpha is the major immunoglobulin class in body secretions. It may serve both to defend against local infection and to prevent access of foreign antigens to the general immunologic system. -
Cellular localization
Secreted
Images
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SDS-PAGE: 4-12% Bis-Tris NuPAGE gel
1. 5 μg Human IgA1 (reduced /heated)
2. 10 μg Human IgA1 (reduced/ heated)
3. 20 μg Human IgA1 (reduced/ heated)
4. Molecular weight markers
5. 5 μg Human IgA1 (non-reduced/no heat)
6. 10 μg Human IgA1 (non-reduced/no heat)
7. 20 μg Human IgA1 (non-reduced/no heat)
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
Datasheets and documents
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SDS download
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Datasheet download
References (6)
ab91020 has been referenced in 6 publications.
- Zhu X et al. Liuwei Dihuang Pills Inhibit Podocyte Injury and Alleviate IgA Nephropathy by Directly Altering Mesangial Cell-Derived Exosome Function and Secretion. Front Pharmacol 13:889008 (2022). PubMed: 35899112
- Yu M et al. Mesangial Cell-Derived Exosomal miR-4455 Induces Podocyte Injury in IgA Nephropathy by Targeting ULK2. Oxid Med Cell Longev 2022:1740770 (2022). PubMed: 36388165
- Sánchez-Salguero E et al. Maternal IgA2 Recognizes Similar Fractions of Colostrum and Fecal Neonatal Microbiota. Front Immunol 12:712130 (2021). PubMed: 34804008
- Xia M et al. Based on Network Pharmacology Tools to Investigate the Mechanism of Tripterygium wilfordii Against IgA Nephropathy. Front Med (Lausanne) 8:794962 (2021). PubMed: 34977095
- Zheng N et al. TLR7 in B cells promotes renal inflammation and Gd-IgA1 synthesis in IgA nephropathy. JCI Insight 5:N/A (2020). PubMed: 32699192
- Sánchez-Salguero E et al. Infectious episodes during pregnancy, at particular mucosal sites, increase specific IgA1 or IgA2 subtype levels in human colostrum. Matern Health Neonatol Perinatol 5:9 (2019). PubMed: 31205733