Native Human IgG3 protein (ab118426)
Key features and details
- Expression system: Native
- Purity: > 95% SDS-PAGE
- Suitable for: SDS-PAGE
Description
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Product name
Native Human IgG3 protein
See all IgG3 proteins and peptides -
Purity
> 95 % SDS-PAGE.
ab118426 is prepared from plasma shown to be non reactive for HBsAg, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA approved tests. -
Expression system
Native -
Accession
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Protein length
Full length protein -
Animal free
No -
Nature
Native -
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Species
Human -
Predicted molecular weight
170 kDa
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Associated products
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Related Products
Specifications
Our Abpromise guarantee covers the use of ab118426 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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Applications
SDS-PAGE
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Form
Liquid -
Concentration information loading...
Preparation and Storage
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Stability and Storage
Shipped at 4°C. Upon delivery aliquot. Store at +4°C. Do Not Freeze.
pH: 7.40
Preservative: 0.05% Sodium azide
Constituents: 0.88% Sodium chloride, 0.3% Sodium phosphate monobasic, monohydrate
General Info
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Alternative names
- DKFZp686H11213
- FLJ39988
- FLJ40036
see all -
Relevance
IgG3, like IgG1, activates complement and has an affinity for fc receptors; thus IgG1 and IgG3 are the more effective of the IgG subclasses. An IgG3 deficiency is associated with Wiscott-Aldrich disease, systemic lupus erythematosus, juvenile diabetes mellitus, and peridontal infections. IgG anti-viral antibodies are restricted to IgG subclasses 1 and 3, with IgG3 antibodies being the first to appear in response to infection. -
Cellular localization
Secreted
Images
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SDS PAGE analysis of ab118426 under reducing conditions (lanes 2-4) and non-reducing conditions (lanes 5-7) on 4 - 12% Bis-Tris NuPAGE gel.
Lane 1: ladder.
Lane 2: 5 μg (reduced / heated)
Lane 3: 10 μg (reduced / heated)
Lane 4: 20 μg (reduced / heated)
Lane 5: 5 μg (non-reduced / no heat)
Lane 6: 10 μg (non-reduced / no heat)
Lane 7: 20 μg (non-reduced / no heat)
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
Datasheets and documents
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SDS download
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Datasheet download
References (3)
ab118426 has been referenced in 3 publications.
- Henson D et al. Association Between ApoA-I (Apolipoprotein A-I) Immune Complexes and Adverse Cardiovascular Events-Brief Report. Arterioscler Thromb Vasc Biol 39:1884-1892 (2019). PubMed: 31315438
- Shiroishi M et al. Structure-function analyses of a stereotypic rheumatoid factor unravel the structural basis for germline-encoded antibody autoreactivity. J Biol Chem 293:7008-7016 (2018). PubMed: 29523691
- Sinkovits G et al. Concentration and Subclass Distribution of Anti-ADAMTS13 IgG Autoantibodies in Different Stages of Acquired Idiopathic Thrombotic Thrombocytopenic Purpura. Front Immunol 9:1646 (2018). PubMed: 30061898