Overview

  • Product name
    Natural Human IgG3 protein
  • Protein length
    Full length protein

Description

  • Nature
    Native
  • Source
    Native
  • Amino Acid Sequence
    • Accession
    • Sequence
      ASTKGPSVFPLAPCSRSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGV HTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYTCNVNHKPSNTKVDKRVEL KTPLGDTTHTCPRCPEPKSCDTPPPCPRCPEPKSCDTPPPCPRCPEPKSC DTPPPCPRCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHED PEVQFKWYVDGVEVHNAKTKPREEQYNSTFRVVSVLTVLHQDWLNGKEYK CKVSNKALPAPIEKTISKTKGQPREPQVYTLPPSREEMTKNQVSLTCLVK GFYPSDIAVEWESSGQPENNYNTTPPMLDSDGSFFLYSKLTVDKSRWQQG NIFSCSVMHEALHNRFTQKSLSLSPGK
    • Molecular weight
      170 kDa
    • Amino acids
      1 to 377
    • Additional sequence information
      Prepared from Human plasma

Specifications

Our Abpromise guarantee covers the use of ab184884 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • Purity
    >95% by SDS-PAGE .

  • Form
    Liquid
  • Additional notes

    Like IgG1, IgG3 activates complement and has an affinity for fc receptors; thus IgG1 and IgG3 are the more effective of the IgG subclasses. An IgG3 deficiency is associated with Wiscott-Aldrich disease, systemic lupus erythematosus, juvenile diabetes mellitus, and peridontal infections. IgG anti-viral antibodies are restricted to IgG subclasses 1 and 3, with IgG3 antibodies being the first to appear in response to infection.

    ab184884 is non reactive for HbsAG, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA approved tests.

     

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at 4°C (stable for up to 12 months). Store at +4°C. Do Not Freeze.

    pH: 7.4
    Preservative: 0.05% Sodium azide
    Constituents: 0.28% Sodium phosphate, 0.88% Sodium chloride

General Info

  • Alternative names
    • DKFZp686H11213
    • FLJ39988
    • FLJ40036
    • FLJ40253
    • FLJ40587
    • FLJ40789
    • FLJ40834
    • G3m marker
    • HDC
    • Heavy chain disease protein
    • Ig gamma 3 chain C region
    • IgG3
    • IGHG 3
    • IGHG3
    • IGHG3 protein
    • Immunoglobulin gamma 3
    • Immunoglobulin gamma 3 (Gm marker)
    • Immunoglobulin heavy constant gamma 3
    • Immunoglobulin heavy constant gamma 3 (G3m marker)
    • MGC45809
    see all
  • Relevance
    IgG is a monomeric immunoglobulin, built of two heavy chains gamma and two light chains. Each molecule has two antigen binding sites. This is the most abundant immunoglobulin and is approximately equally distributed in blood and in tissue liquids, constituting 75% of serum immunoglobulins in humans. There are 4 subclasses: IgG1 (66%), IgG2 (23%), IgG3 (7%) and IgG4 (4%).
  • Cellular localization
    Secreted

Images

  • Lane 1: Human IgG3 (20µl) Non reducing

    Lane 2: Human IgG3 (10µl) Non reducing

    Lane 3: Human IgG3 (5µl) Non reducing

    Lane 4: Human IgG3 (20µl) Reducing

    Lane 5: Human IgG3 (10µl) Reducing

    Lane 6: Human IgG3 (5µl) Reducing

    Lane 7: Molecular weigth marker

References

ab184884 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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