Overview

  • Product nameNatural Human IgM Kappa protein
  • Protein lengthFull length protein

Description

  • NatureNatural
  • SourceNative
  • Amino Acid Sequence
    • AccessionP01871
    • SpeciesHuman
    • Molecular weight49 kDa
    • Amino acids1 to 452

Specifications

Our Abpromise guarantee covers the use of ab99015 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • Purity> 95 % SDS-PAGE.

  • FormLiquid
  • Additional notesStarting material tested and found negative for HIV I & II antibodies, Hepatits B surface antigen and Hepatitis C antibodies.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -20ºC. Avoid freeze / thaw cycles.

    Preservative: 0.05% Sodium Azide
    Constituents: 0.2M Sodium chloride, 50mM Tris, pH 8.0

General Info

  • Alternative names
    • Ig mu chain C region
    • IGHM
  • RelevanceIgM normally constitutes about 10% of serum immunoglobulins. IgM antibody is prominent in early immune responses to most antigens and predominates in certain antibody responses such as 'natural' blood group antibodies. IgM (with IgD) is the major immunoglobulin expressed on the surface of B cells. The gene for the mu constant region contains four domains separated by short intervening sequences. Immunoglobulin (Ig) molecules consist of two chains, one heavy chain (which can be alpha, delta, epsilon, gamma or mu) and one light chain (which can be kappa or lambda) each consisting of a variable and a constant region. An IgM molecule contains thus a mu heavy chain combined with either a kappa or a lambda light chains. It is found almost exclusively as an homopentamer in the serum. Membrane-bound IgM molecules are non-covalently associated with heterodimer of CD79A and CD79B.
  • Cellular localizationIsoform 1: Secreted. Isoform 2: Cell membrane; Single-pass type I membrane protein.

References for Natural Human IgM Kappa protein (ab99015)

ab99015 has not yet been referenced specifically in any publications.

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