The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Biological activityActivity: 180-220 units per mg protein after lyophilization. One unit is defined as the amount of enzyme that will decompose 1.0 micromole of hydrogen peroxide per minute at 25°C, pH 6.0.
% SDS-PAGE. ab77886 is purified by column chromatography.
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Preparation and Storage
Stability and Storage
Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C.
This product is an active protein and may elicit a biological response in vivo, handle with caution.
ReconstitutionReconstitute with 25.8ul distilled water.
84 kDa myeloperoxidase
89 kDa myeloperoxidase
Myeloperoxidase heavy chain
Myeloperoxidase light chain
FunctionPart of the host defense system of polymorphonuclear leukocytes. It is responsible for microbicidal activity against a wide range of organisms. In the stimulated PMN, MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance PMN microbicidal activity.
Involvement in diseaseDefects in MPO are the cause of myeloperoxidase deficiency (MPD) [MIM:254600]. MPD is an autosomal recessive defect that results in disseminated candidiasis.
Sequence similaritiesBelongs to the peroxidase family. XPO subfamily.