FunctionPart of the host defense system of polymorphonuclear leukocytes. It is responsible for microbicidal activity against a wide range of organisms. In the stimulated PMN, MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance PMN microbicidal activity.
Involvement in diseaseDefects in MPO are the cause of myeloperoxidase deficiency (MPD) [MIM:254600]. MPD is an autosomal recessive defect that results in disseminated candidiasis.
Sequence similaritiesBelongs to the peroxidase family. XPO subfamily.
References for Natural Human Myeloperoxidase protein (ab98926)
This product has been referenced in:
Moral-Vico J et al. Dual chronoamperometric detection of enzymatic biomarkers using magnetic beads and a low-cost flow cell. Biosens Bioelectron69:328-36 (2015).
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Herrasti Z et al. Carbon nanotube wiring for signal amplification of electrochemical magneto immunosensors: application to myeloperoxidase detection. Anal Bioanal Chem406:5487-93 (2014).
Read more (PubMed: 24994664) »