Natural human Plasmin protein (ab84406)



  • NatureNatural
  • SourceNative
  • Amino Acid Sequence
    • SpeciesHuman


Our Abpromise guarantee covers the use of ab84406 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Biological activitySpecific Activity: 16.2 units/mg. One unit is defined as the amount of enzyme that will hydrolyze 1 umole of tosyl-Gly-Pro-Lys-pNA per minute at 25°C, pH 7.8. One unit = 1.25 CU.
  • FormLiquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -20ºC. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 25% Glycerol, 100mM Sodium phosphate, 1mM EACA, pH 7.3

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

General Info

  • Alternative names
    • Plasminogen
    • PLG
  • RelevancePlasmin is an enzyme formed in the circulating blood, and many other extracellular fluids, from the zymogen plasminogen. Plasminogen is a single-chain glycoprotein with 790 amino acid residues. Activation to the active form, plasmin, by urokinase involves cleavage at the arg-val bond between residues 560 and 561, resulting in the formation of the 2-chain plasmin molecule held together by 2 disulfide linkages. The heavier chain contains about 411 residues and the lighter chain about 233. The main function of plasmin is the digestion of fibrin in blood clots. Plasmin is a proteolytic enzyme with a specificity similar to that of trypsin. Like trypsin, plasmin belongs to the family of serine proteinases, in which the active site catalytic triad, his-57, asp-102, and ser-195 (chymotrypsin numbering), is situated in the light chain. Plasmin acts as a proteolytic factor in a variety of processes other than fibrinolysis; including embryonic development, tissue remodelling, tumour invasion and inflammation; in ovulation it weakens the walls of the Graafian follicle. A Deficiency of plasmin may lead to thrombosis, as clots are not degraded adequately.
  • Cellular localizationSecreted

References for Natural human Plasmin protein (ab84406)

ab84406 has not yet been referenced specifically in any publications.

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How was the protein purified from plasma? – Answer from lab: We do not disclose out purification methods, but a qu...

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Thank you for contacting Abcam regarding ab84406.

The activity for this protein (one unit) is defined as the amount of enzyme that will hydrolyze 1 umole of tosyl-Gly-Pro-Lys-pNA per minute at 25oC, pH 7.8. This assay is performed using 0...

Read More