The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
% . ab96056 is sterile filtered through a 0.2µm membrane. Nominally greater than 96% purity. Precipitin band visible in Immunological analysis by Ouchterlony immunodiffusion vs Rabbit anti SAP.
Additional notesStarting material donor tested and certified negative for HIV I & II antibodies, Hepatitis B surface antigen and Hepatitis C antibodies.
Optical density at 280nm using E (1cm, 0.1%) = 1.95.
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Preparation and Storage
Stability and Storage
Shipped at 4°C. Store at +4°C.
pH: 8.00 Constituent: Tris buffered saline
9.5S alpha 1 glycoprotein
Amyloid P component serum
Serum amyloid P component
Serum amyloid P-component(1-203)
FunctionCan interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells. May also function as a calcium-dependent lectin.
Tissue specificityFound in serum and urine.
Involvement in diseaseNote=SAP is a precursor of amyloid component P which is found in basement membrane and associated with amyloid deposits.
Sequence similaritiesBelongs to the pentaxin family. Contains 1 pentaxin domain.
Post-translational modificationsN-glycosylated with a complex biantennary oligosaccharide chain with a sialic acid at the end (disialo-SAP). Monosialo-SAP as well as asioalo-SAP are also detected (PubMed:15174148).