Natural Human Serum Amyloid P protein (ab96056)

Overview

Description

  • Nature
    Native
  • Source
    Native
  • Amino Acid Sequence
    • Accession
    • Species
      Human
    • Molecular weight
      25 kDa
    • Amino acids
      20 to 223

Specifications

Our Abpromise guarantee covers the use of ab96056 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

    Western blot

  • Purity
    96 % .
    ab96056 is sterile filtered through a 0.2µm membrane. Nominally greater than 96% purity. Precipitin band visible in Immunological analysis by Ouchterlony immunodiffusion vs Rabbit anti SAP.
  • Form
    Liquid
  • Additional notes
    Starting material donor tested and certified negative for HIV I & II antibodies, Hepatitis B surface antigen and Hepatitis C antibodies. Optical density at 280nm using E (1cm, 0.1%) = 1.95.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at +4°C.

    pH: 8.00
    Constituent: Tris buffered saline

General Info

  • Alternative names
    • 9.5S alpha 1 glycoprotein
    • 9.5S alpha-1-glycoprotein
    • Amyloid P component serum
    • APCS
    • MGC88159
    • Pentaxin related
    • Pentraxin 2
    • PTX 2
    • PTX2
    • SAMP_HUMAN
    • SAP
    • Serum amyloid P component
    • Serum amyloid P-component(1-203)
    see all
  • Function
    Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells. May also function as a calcium-dependent lectin.
  • Tissue specificity
    Found in serum and urine.
  • Involvement in disease
    Note=SAP is a precursor of amyloid component P which is found in basement membrane and associated with amyloid deposits.
  • Sequence similarities
    Belongs to the pentaxin family.
    Contains 1 pentaxin domain.
  • Post-translational
    modifications
    N-glycosylated with a complex biantennary oligosaccharide chain with a sialic acid at the end (disialo-SAP). Monosialo-SAP as well as asioalo-SAP are also detected (PubMed:15174148).
  • Cellular localization
    Secreted.
  • Information by UniProt

Images

  • Anti-Serum Amyloid P antibody (ab66715) at 1 µg/ml + Natural Human Serum Amyloid P protein (ab96056) at 0.01 µg

    Secondary
    Goat Anti-Rabbit IgG H&L (HRP) preadsorbed (ab97080) at 1/5000 dilution
    Developed using the ECL technique

    Performed under reducing conditions.

    Exposure time : 1 minute

References

ab96056 has not yet been referenced specifically in any publications.

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