Natural Human Thyroglobulin protein (ab96518)

Overview

Description

  • NatureNatural
  • SourceNative
  • Amino Acid Sequence
    • AccessionP01266
    • SpeciesHuman
    • Molecular weight303 kDa
    • Amino acids20 to 2768

Specifications

Our Abpromise guarantee covers the use of ab96518 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Radial Immunodiffusion

    SDS-PAGE

    Western blot

  • Purity>= 96 % SDS-PAGE.
    Nominally greater than 96% of the protein is Thyroglobulin.
  • FormLyophilised
  • Additional notesStarting material pool is tested and found negative for HIV I & II antibodies, Hepatitis B surface antigen, and Hepatitis C antibodies.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at +4°C.

    Constituent: 0.2% Ammonium bicarbonate
    Note: May contain traces of buffer salts.

  • ReconstitutionUse of phosphate buffer, pH >7.0 containing 0.15M NaCl is recommended.

General Info

  • Alternative names
    • AITD 3
    • AITD3
    • hTG
    • TDH3
    • Tg
    • TGN
    • THYG_HUMAN
    • Thyroglobulin
    see all
  • FunctionPrecursor of the iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3).
  • Tissue specificityThyroid gland specific.
  • Involvement in diseaseDefects in TG are the cause of congenital hypothyroidism due to dyshormonogenesis type 3 (CHDH3) [MIM:274700]. A disorder due to thyroid dyshormonogenesis, causing large goiters of elastic and soft consistency in the majority of patients. Although the degree of thyroid dysfunction varies considerably among patients with defective thyroglobulin synthesis, patients usually have a relatively high serum free triiodothyronine (T3) concentration with disproportionately low free tetraiodothyronine (T4) level. The maintenance of relatively high free T3 levels prevents profound tissue hypothyroidism except in brain and pituitary, which are dependent on T4 supply, resulting in neurologic and intellectual defects in some cases.
    Variations in TG are associated with susceptibility to autoimmune thyroid disease type 3 (AITD3) [MIM:608175]. AITDs including Graves disease (GD) and Hashimoto thyroiditis (HT), are among the most common human autoimmune diseases. They are complex diseases, which are caused by an interaction between susceptibility genes and nongenetic factors, such as infection.
  • Sequence similaritiesBelongs to the type-B carboxylesterase/lipase family.
    Contains 11 thyroglobulin type-1 domains.
  • Post-translational
    modifications
    Sulfated tyrosines are desulfated during iodination.
  • Cellular localizationSecreted.
  • Information by UniProt

Natural Human Thyroglobulin protein images

  • Anti-Thyroglobulin antibody (ab48628) at 5 µg/ml + Natural Human Thyroglobulin protein (ab96518) at 0.01 µg

    Secondary
    Goat Anti-Rabbit IgG H&L (HRP) preadsorbed (ab97080) at 1/5000 dilution
    Developed using the ECL technique

    Performed under reducing conditions.

    Exposure time : 10 seconds

References for Natural Human Thyroglobulin protein (ab96518)

ab96518 has not yet been referenced specifically in any publications.

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