Natural Human TIMP2 protein (ab39314)

Overview

Description

  • Nature
    Native
  • Source
    Native
  • Amino Acid Sequence 1
    • Species
      Human
    Amino Acid Sequence 2
    • Species
      Human

Specifications

Our Abpromise guarantee covers the use of ab39314 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Western blot

    ELISA

  • Purity
    > 95 % SDS-PAGE.
    TIMP2 is purified from human fibroblasts, and is essentially free of contaminating MMPs or other known TIMPs.
  • Form
    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 50% Glycerol, PBS, pH 7.4

General Info

  • Alternative names
    • CSC 21K
    • CSC-21K
    • CSC21K
    • Metalloproteinase inhibitor 2
    • Metalloproteinase inhibitor 2 precursor
    • TIMP 2
    • TIMP metallopeptidase inhibitor 2
    • TIMP-2
    • TIMP2
    • TIMP2_HUMAN
    • Tissue Inhibitor of Metalloproteinase 2
    • Tissue inhibitor of metalloproteinases 2
    see all
  • Function
    Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-13, MMP-14, MMP-15, MMP-16 and MMP-19.
  • Sequence similarities
    Belongs to the protease inhibitor I35 (TIMP) family.
    Contains 1 NTR domain.
  • Post-translational
    modifications
    The activity of TIMP2 is dependent on the presence of disulfide bonds.
  • Cellular localization
    Secreted.
  • Information by UniProt

References

ab39314 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

Thank you for contacting Abcam.
The molecular weight of ab39314 is 24,398g/mol and the extinction co-efficient is 33160cm-1M-1. Unfortunately I do not have any information on its use for titration of mmp14
If there is anything else I can help...

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