Natural Human TIMP2 protein (ab39314)

Overview

Description

  • Nature
    Native
  • Source
    Native
  • Amino Acid Sequence 1
    • Species
      Human
    Amino Acid Sequence 2
    • Species
      Human

Specifications

Our Abpromise guarantee covers the use of ab39314 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Western blot

    ELISA

  • Purity
    > 95 % SDS-PAGE.
    TIMP2 is purified from human fibroblasts, and is essentially free of contaminating MMPs or other known TIMPs.
  • Form
    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 50% Glycerol, PBS, pH 7.4

General Info

  • Alternative names
    • CSC 21K
    • CSC-21K
    • CSC21K
    • Metalloproteinase inhibitor 2
    • Metalloproteinase inhibitor 2 precursor
    • TIMP 2
    • TIMP metallopeptidase inhibitor 2
    • TIMP-2
    • TIMP2
    • TIMP2_HUMAN
    • Tissue Inhibitor of Metalloproteinase 2
    • Tissue inhibitor of metalloproteinases 2
    see all
  • Function
    Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-13, MMP-14, MMP-15, MMP-16 and MMP-19.
  • Sequence similarities
    Belongs to the protease inhibitor I35 (TIMP) family.
    Contains 1 NTR domain.
  • Post-translational
    modifications
    The activity of TIMP2 is dependent on the presence of disulfide bonds.
  • Cellular localization
    Secreted.
  • Information by UniProt

References for Natural Human TIMP2 protein (ab39314)

ab39314 has not yet been referenced specifically in any publications.

Product Wall

Thank you for contacting Abcam.
The molecular weight of ab39314 is 24,398g/mol and the extinction co-efficient is 33160cm-1M-1. Unfortunately I do not have any information on its use for titration of mmp14
If there is anything else I can help...

Read More

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

Sign up