Natural Human Urokinase protein (ab51966)

Overview

Description

  • NatureNatural
  • SourceNative
  • Amino Acid Sequence
    • SpeciesHuman

Specifications

Our Abpromise guarantee covers the use of ab51966 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Biological activitySource: Human urine Ab51966 is a two-chain glycoprotein containing 411 amino acids with 12 dissulfide bonds. Its molecular weight is 54 kDa.
  • Applications

    SDS-PAGE

  • Purity> 90 % SDS-PAGE.
    ab51966 purity was assessed also by HPLC. Endotoxin: Less than 0.1 ng/mg of human Urokinase
  • FormLyophilised
  • Additional notesSource: Human urine Ab51966 is a two-chain glycoprotein containing 411 amino acids with 12 dissulfide bonds. Its molecular weight is 54 kDa.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

  • ReconstitutionReconstitute in sterile water to a concentration >100 µg/ml. Add a carrier protein (0.1% HSA or BSA) for extrastability.

General Info

  • Alternative names
    • ATF
    • ATF uPA
    • BDPLT5
    • Plasminogen activator
    • Plasminogen activator urinary
    • Plasminogen activator urokinase
    • PLAU
    • QPD
    • u PA
    • U plasminogen activator
    • u-PA
    • U-plasminogen activator
    • uPA
    • URK
    • UROK_HUMAN
    • Urokinase plasminogen activator
    • Urokinase type plasminogen activator
    • Urokinase type plasminogen activator precursor
    • Urokinase-type plasminogen activator chain B
    see all
  • FunctionSpecifically cleave the zymogen plasminogen to form the active enzyme plasmin.
  • Tissue specificityExpressed in the prostate gland and prostate cancers.
  • Sequence similaritiesBelongs to the peptidase S1 family.
    Contains 1 EGF-like domain.
    Contains 1 kringle domain.
    Contains 1 peptidase S1 domain.
  • Post-translational
    modifications
    Phosphorylation of Ser-158 and Ser-323 abolishes proadhesive ability but does not interfere with receptor binding.
  • Cellular localizationSecreted.
  • Information by UniProt

References for Natural Human Urokinase protein (ab51966)

ab51966 has not yet been referenced specifically in any publications.

Product Wall

Thank you for your enquiry. This product was lyophilized from a concentrated (1mg/ml) solution containing phosphate buffer and hence is Tris free.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"