Overview

Description

  • NatureNatural
  • SourceNative
  • Amino Acid Sequence
    • SpeciesHuman

Specifications

Our Abpromise guarantee covers the use of ab91031 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Western blot

    ELISA

  • Purity> 95 % SDS-PAGE.
    Native protein isolated from Human urine.
  • FormLyophilised
  • Additional notesProduct is not sterile. Please filter the product by an appropriate sterile filter before using it in the cell culture.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot. Store at -80°C. Avoid freeze / thaw cycle.

    Preservative: None
    Constituents: ddH20

  • ReconstitutionAdd 200ul deionized water and let the lyophilized pellet dissolve completely.

General Info

  • Alternative names
    • ADMCKD2
    • FJHN
    • HNFJ
    • HNFJ1
    • MCKD2
    • medullary cystic kidney disease 2 (autosomal dominant)
    • Tamm Horsfall glycoprotein
    • Tamm Horsfall urinary glycoprotein
    • Tamm-Horsfall urinary glycoprotein
    • THGP
    • THP
    • Umod
    • Urehd1
    • urehr4
    • UROM_HUMAN
    • Uromodulin
    • uromodulin (uromucoid, Tamm-Horsfall glycoprotein)
    • Uromodulin, secreted form
    see all
  • FunctionNot known. May play a role in regulating the circulating activity of cytokines as it binds to IL-1, IL-2 and TNF with high affinity.
  • Tissue specificitySynthesized by kidney. Most abundant protein in normal human urine.
  • Involvement in diseaseDefects in UMOD are the cause of familial juvenile hyperuricemic nephropathy type 1 (HNFJ1) [MIM:162000]. HNFJ1 is a renal disease characterized by juvenil onset of hyperuricemia, polyuria, progressive renal failure, and gout. The disease is associated with interstitial pathological changes resulting in fibrosis.
    Defects in UMOD are the cause of medullary cystic kidney disease type 2 (MCKD2) [MIM:603860]. MCKD2 is a form of tubulointerstitial nephropathy characterized by formation of renal cysts at the corticomedullary junction. It is characterized by adult onset of impaired renal function and salt wasting resulting in end-stage renal failure by the sixth decade.
    Defects in UMOD are the cause of glomerulocystic kidney disease with hyperuricemia and isosthenuria (GCKDHI) [MIM:609886]. GCKDHI is a renal disorder characterized by a cystic dilation of Bowman space, a collapse of glomerular tuft, and hyperuricemia due to low fractional excretion of uric acid and severe impairment of urine concentrating ability.
  • Sequence similaritiesContains 3 EGF-like domains.
    Contains 1 ZP domain.
  • Cellular localizationCell membrane. Secreted. Secreted after cleavage in the urine.
  • Information by UniProt

Natural Human Uromucoid protein images

  • 12% SDS Page analysis of ab91031.
    1. M.W. marker: 14, 21, 31, 45, 66, 97 kDa
    2. 5ug ab91031, reduced and heated
    3. 5ug ab91031, native

References for Natural Human Uromucoid protein (ab91031)

ab91031 has not yet been referenced specifically in any publications.

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