Overview

Description

  • Nature
    Native
  • Source
    Native
  • Amino Acid Sequence
    • Species
      Human

Specifications

Our Abpromise guarantee covers the use of ab77899 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • Purity
    > 95 % SDS-PAGE.

  • Form
    Lyophilised
  • Additional notes
    All human source materials have tested negative for HIV 1 and HIV 2 and non-reactive for HBsAg, anti-HCV and anti-HBc by FDA required tests. No test guarantees a product to be non-infectious. Therefore, all material derived from human fluids or tissues should be considered as potentially infectious.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Preservative: None
    Constituents: 20mM Sodium phosphate, 150mM Sodium chloride, pH 7.4

  • Reconstitution
    Reconstitute with 227ul distilled water.

General Info

  • Alternative names
    • DBP
    • DBP/GC
    • GC
    • Gc globulin
    • Gc-globulin
    • GRD3
    • Group specific component
    • Group specific component vitamin D binding protein
    • Group-specific component
    • hDBP
    • VDB
    • VDBG
    • VDBP
    • Vitamin D binding alpha globulin
    • Vitamin D-binding protein
    • VTDB_HUMAN
    see all
  • Function
    Multifunctional protein found in plasma, ascitic fluid, cerebrospinal fluid, and urine and on the surface of many cell types. In plasma, it carries the vitamin D sterols and prevents polymerization of actin by binding its monomers. DBP associates with membrane-bound immunoglobulin on the surface of B-lymphocytes and with IgG Fc receptor on the membranes of T-lymphocytes.
  • Sequence similarities
    Belongs to the ALB/AFP/VDB family.
    Contains 3 albumin domains.
  • Cellular localization
    Secreted.
  • Information by UniProt

References

This product has been referenced in:
  • Behrouz GF  et al. Presence of auto-antibody against two placental proteins, annexin A1 and vitamin D binding protein, in sera of women with pre-eclampsia. J Reprod Immunol 99:10-6 (2013). WB . Read more (PubMed: 23830177) »
  • Sohn DH  et al. Plasma proteins present in osteoarthritic synovial fluid can stimulate cytokine production via Toll-like receptor 4. Arthritis Res Ther 14:R7 (2012). Read more (PubMed: 22225630) »

See all 2 Publications for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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