The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Biological activity86.8 U/mg determined by Factor X clotting assay (1 unit is equivalent to the Factor X activity in 1 ml normal plasma based on a Human plasma standard curve).
86.8 U/mg determined by Factor X clotting assay (1 unit is equivalent to the Factor X activity in 1 ml normal plasma based on a Human plasma standard curve).
% SDS-PAGE. ab96742 is isolated from fresh frozen plasma by a combination of conventional techniques and immunoaffinity chromatography.
Concentration information loading...
Preparation and Storage
Stability and Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Constituents: 50% Glycerol
This product is an active protein and may elicit a biological response in vivo, handle with caution.
Activated factor Xa heavy chain
Coagulation factor X
Stuart Prower factor
FunctionFactor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting.
Tissue specificityPlasma; synthesized in the liver.
Involvement in diseaseDefects in F10 are the cause of factor X deficiency (FA10D) [MIM:227600]. A hemorrhagic disease with variable presentation. Affected individuals can manifest prolonged nasal and mucosal hemorrhage, menorrhagia, hematuria, and occasionally hemarthrosis. Some patients do not have clinical bleeding diathesis.
Post-translational modificationsThe vitamin K-dependent, enzymatic carboxylation of some glutamate residues allows the modified protein to bind calcium. N- and O-glycosylated. The activation peptide is cleaved by factor IXa (in the intrinsic pathway), or by factor VIIa (in the extrinsic pathway). The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.