Overview

Description

  • Nature
    Native
  • Source
    Native
  • Amino Acid Sequence
    • Accession
    • Species
      Rat
    • Molecular weight
      80 kDa
    • Additional sequence information
      Prepared from rat plasma.

Specifications

Our Abpromise guarantee covers the use of ab198663 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • Purity
    >= 98 % SDS-PAGE.

  • Form
    Lyophilised
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at -80°C. Avoid freeze / thaw cycle.

    pH: 7.4
    Constituents: 0.33% Sodium phosphate, 0.87% Sodium chloride

  • Reconstitution
    We suggest the addition of de-ionized H2O to the original volume, followed by gentle swirling and/or vortexing to ensure adequate homogenization. If further dilution is required, we suggest using the lyophilization buffer.

General Info

  • Alternative names
    • Apotransferrin
    • Beta 1 metal binding globulin
    • Beta-1 metal-binding globulin
    • DKFZp781D0156
    • PRO1400
    • PRO1557
    • PRO2086
    • Serotransferrin
    • Serotransferrin precursor
    • Siderophilin
    • TF
    • TFQTL1
    • Transferin
    • Transferrin
    • TRFE_HUMAN
    see all
  • Function
    Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation.
  • Tissue specificity
    Expressed by the liver and secreted in plasma.
  • Involvement in disease
    Defects in TF are the cause of atransferrinemia (ATRAF) [MIM:209300]. Atransferrinemia is rare autosomal recessive disorder characterized by iron overload and hypochromic anemia.
  • Sequence similarities
    Belongs to the transferrin family.
    Contains 2 transferrin-like domains.
  • Cellular localization
    Secreted.
  • Information by UniProt

Images

  • SDS PAGE analysis of ab198663:
    Lane 1: 5 μg, under reduced and heated conditions;
    Lane 2: 10 μg, under reduced and heated conditions;
    Lane 3: 20 μg, under reduced and heated conditions.
    Lane 4: 5 μg, under non reduced and not heated conditions;
    Lane 5: 10 μg, under non reduced and not heated conditions;
    Lane 6: 20 μg, under non reduced and not heated conditions.

References

ab198663 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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