SpecificityIn preliminary western blot experiments ab114110 gave an ~150kDa band in Rat spinal cord and Mouse NIH3T3 lysates at 1ug/ml. This band was blocked by addition of the immunizing peptide. Please note that currently we cannot find an explanation in the literature for the band we observe given the calculated size of 221kDa according to NP_033160.2.
Mouse, Rat Predicted to work with:
, corresponding to internal sequence amino acids 471-484 of Mouse Nav1.8 (NP_033160.2).
Fast track antibodies constitute a diverse group of products that have been released to accelerate your research, but are not yet fully characterized. They have all been affinity purified and show high titre values against the immunizing peptide (by ELISA).
Use at an assay dependent concentration. Predicted molecular weight: 1 kDa.
RelevanceNav1.8 protein mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, Nav1.8 forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-resistant sodium channel isoform. Nav1.8 plays a role in neuropathic pain mechanisms.
Cellular localizationIntegral membrane protein. Nav1.8 can be translocated to the extracellular membrane through association with S100A10.