This fast track antibody is not yet fully characterized. It is subject to these terms and conditions

Overview

  • Product nameAnti-Nav1.8 antibody
    See all Nav1.8 primary antibodies
  • Description
    Goat polyclonal to Nav1.8

    This product is a fast track antibody. It has been affinity purified and shows high titre values against the immunizing peptide by ELISA. Read the terms of use »

  • SpecificityIn preliminary western blot experiments ab114110 gave an ~150kDa band in Rat spinal cord and Mouse NIH3T3 lysates at 1ug/ml. This band was blocked by addition of the immunizing peptide. Please note that currently we cannot find an explanation in the literature for the band we observe given the calculated size of 221kDa according to NP_033160.2.
  • Species reactivity
    Reacts with: Mouse, Rat
    Predicted to work with: Dog
  • Immunogen

    Synthetic peptide:

    C-DDNRSLQSDPYNQR

    , corresponding to internal sequence amino acids 471-484 of Mouse Nav1.8 (NP_033160.2).

Properties

  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • Storage bufferpH: 7.30
    Preservative: 0.02% Sodium azide
    Constituents: 0.5% BSA, 99.48% Tris buffered saline
  • Concentration information loading...
  • PurityImmunogen affinity purified
  • Purification notesab114110 was purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
  • ClonalityPolyclonal
  • IsotypeIgG
  • Research areas

Applications

Fast track antibodies constitute a diverse group of products that have been released to accelerate your research, but are not yet fully characterized. They have all been affinity purified and show high titre values against the immunizing peptide (by ELISA). Fast track terms of use

Application Abreviews Notes
WB Use at an assay dependent concentration. Predicted molecular weight: 1 kDa.

Target

  • FunctionTetrodotoxin-resistant channel that mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient. Plays a role in neuropathic pain mechanisms.
  • Tissue specificityExpressed in the dorsal root ganglia and sciatic nerve.
  • Involvement in diseaseEpisodic pain syndrome, familial, 2
  • Sequence similaritiesBelongs to the sodium channel (TC 1.A.1.10) family. Nav1.8/SCN10A subfamily.
    Contains 1 IQ domain.
  • DomainThe sequence contains 4 internal repeats, each with 5 hydrophobic segments (S1,S2,S3,S5,S6) and one positively charged segment (S4). Segments S4 are probably the voltage-sensors and are characterized by a series of positively charged amino acids at every third position.
  • Post-translational
    modifications
    Ubiquitinated by NEDD4L; which promotes its endocytosis.
    Phosphorylation at Ser-1451 by PKC in a highly conserved cytoplasmic loop slows inactivation of the sodium channel and reduces peak sodium currents.
  • Cellular localizationCell membrane. It can be translocated to the cell membrane through association with S100A10.
  • Information by UniProt
  • Database links
  • Alternative names
    • hPN3 antibody
    • mPN3 antibody
    • Peripheral nerve sodium channel 3 antibody
    • Pn3 (gene name) antibody
    • PN3 antibody
    • SCN10A antibody
    • SCNAA_HUMAN antibody
    • Sensory neuron sodium channel antibody
    • Sns (gene name) antibody
    • SNS antibody
    • Sodium channel protein type 10 subunit alpha antibody
    • Sodium channel protein type X alpha subunit antibody
    • Sodium channel protein type X subunit alpha antibody
    • Voltage-gated sodium channel alpha subunit Nav1.8 antibody
    • Voltage-gated sodium channel subunit alpha Nav1.8 antibody
    see all

References for Anti-Nav1.8 antibody (ab114110)

ab114110 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab114110.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"