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Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Preservative: 15mM Sodium Azide
Constituents: 0.01M PBS, pH 7.4
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Immunogen affinity purified
ab69868 is affinity-purified using the immunizing peptide immobilized on agarose.
Abpromise guarantee covers the use of
in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 256 kDa.
Staining of the NAV3 band by immunoblotting is specifically inhibited by the NAV3 immunizing peptide.
May regulate IL2 production by T-cells. May be involved in neuron regeneration.
Highly expressed in brain. Expressed at low levels in heart and placenta. Present in activated T-cells but not in resting T-cells (at protein level). Down-regulated in primary neuroblastoma.
Involvement in disease
A chromosomal aberration disrupting NAV3 has been found in patients with Sezary syndrome (PubMed:16166283). Translocation t(12;18)(q21;q21.2) (PubMed:16166283).
Belongs to the Nav/unc-53 family.
Contains 1 CH (calponin-homology) domain.
Expressed in fetal brain.
Nucleus outer membrane.
Information by UniProt
There are 3 isoforms produced by alternative splicing.
NAV 3 antibody
References for Anti-NAV3 antibody (ab69868)
This product has been referenced in:
et al. Aberrant microRNA expression in the brains of neurodegenerative diseases: miR-29a decreased in Alzheimer disease brains targets neuron navigator-3. Neuropathol Appl Neurobiol : (2010).
Read more (PubMed: 20202123) »
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"