The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 256 kDa.
Staining of the NAV3 band by immunoblotting is specifically inhibited by the NAV3 immunizing peptide.
FunctionMay regulate IL2 production by T-cells. May be involved in neuron regeneration.
Tissue specificityHighly expressed in brain. Expressed at low levels in heart and placenta. Present in activated T-cells but not in resting T-cells (at protein level). Down-regulated in primary neuroblastoma.
Involvement in diseaseA chromosomal aberration disrupting NAV3 has been found in patients with Sezary syndrome (PubMed:16166283). Translocation t(12;18)(q21;q21.2) (PubMed:16166283).
Sequence similaritiesBelongs to the Nav/unc-53 family. Contains 1 CH (calponin-homology) domain.
FormThere are 3 isoforms produced by alternative splicing.
NAV 3 antibody
Neuron navigator 3 antibody
Pore membrane and/or filament-interacting-like protein 1 antibody
Steerin 3 antibody
Unc 53 homolog 3 antibody
Unc-53 homolog 3 antibody
References for Anti-NAV3 antibody (ab69868)
This product has been referenced in:
Shioya M et al. Aberrant microRNA expression in the brains of neurodegenerative diseases: miR-29a decreased in Alzheimer disease brains targets neuron navigator-3. Neuropathol Appl Neurobiol : (2010).
Read more (PubMed: 20202123) »