Overview

  • Product nameNBQX disodium salt
  • Description
    AMPA / kainate antagonist; water soluble
  • Biological descriptionWater soluble, potent, selective and competitive AMPA/kainate receptor antagonist. Neuroprotective and anticonvulsant in vivo.

    Also available in simple stock solutions (ab144489) - add 1 ml of water to get an exact, ready-to-use concentration.
  • Purity> 98%

Properties

    Applications

    Our Abpromise guarantee covers the use of ab120046 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    Application Abreviews Notes
    Functional Studies Use at an assay dependent concentration.

    NBQX disodium salt images

    • ab96379 staining MEK1 (phospho S298) in SK-N-SH cells treated with NBQX disodium salt (ab120046), by ICC/IF. Decrease in MEK1 (phospho S298) expression correlates with increased concentration of NBQX disodium salt, as described in literature.
      The cells were incubated at 37°C for 24h in media containing different concentrations of ab120046 (NBQX disodium salt) in DMSO, fixed with 4% formaldehyde for 10 minutes at room temperature and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab96379 (1/100 dilution) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight 488 goat anti-rabbit polyclonal antibody (ab96899) at 1/250 dilution was used as the secondary antibody.

    References for NBQX disodium salt (ab120046)

    This product has been referenced in:
    • Kew JN & Kemp JA Ionotropic and metabotropic glutamate receptor structure and pharmacology. Psychopharmacology (Berl) 179:4-29 (2005). Read more (PubMed: 15731895) »
    • Randle JC  et al. Competitive inhibition by NBQX of kainate/AMPA receptor currents and excitatory synaptic potentials: importance of 6-nitro substitution. Eur J Pharmacol 215:237-44 (1992). Read more (PubMed: 1382998) »
    • Sheardown MJ  et al. 2,3-Dihydroxy-6-nitro-7-sulfamoyl-benzo(F)quinoxaline: a neuroprotectant for cerebral ischemia. Science 247:571-4 (1990). Read more (PubMed: 2154034) »

    See all 8 Publications for this product

    Product Wall

    The molecular weight is batch related so please use what is written on vial. You can also counter check it in the certificate of analysis published on the website.

    Thank you for contacting us.

    I have checked with the lab, and we can confirm that this compound NBQX ab120045 is not soluble in water and is actually only soluble in DMSO to 100 mM.Thiswas a mistake in our database which has now been updated....

    Read More

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"