Overview

  • Product name
  • Description
    Rabbit polyclonal to NBR1
  • Tested applications
    Suitable for: WB, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant fragment, corresponding to a region within amino acids 389-678 of Human NBR1 (UniProt Q14596).

  • Positive control
    • Jurkat whole cell lysate; 293T and A431 cell lysates; Human Breast Cancer tissue

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • Storage buffer
    pH: 7.00
    Preservative: 0.01% Thimerosal (merthiolate)
    Constituents: 78% PBS, 20% Glycerol, 1% BSA
  • Concentration information loading...
  • Purity
    Immunogen affinity purified
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab126175 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 107 kDa.
IHC-P 1/100 - 1/500. Perform heat mediated antigen retrieval before commencing with IHC staining protocol.

Target

  • Function
    Acts probably as a receptor for selective autophagosomal degradation of ubiquitinated targets.
  • Sequence similarities
    Contains 1 OPR domain.
    Contains 1 UBA domain.
    Contains 1 ZZ-type zinc finger.
  • Domain
    The OPR domain mediates interaction with SQSTM1.
  • Cellular localization
    Cytoplasm. Cytoplasmic vesicle > autophagosome. Lysosome. Cytoplasm > myofibril > sarcomere > M line. In cardiac muscles localizes to the sarcomeric M line (By similarity). Is targeted to lysosomes for degradation.
  • Information by UniProt
  • Database links
  • Alternative names
    • 1A1 3B antibody
    • 1A13B antibody
    • B box protein antibody
    • Cell migration-inducing gene 19 protein antibody
    • KIAA0049 antibody
    • M17S2 antibody
    • Membrane component chromosome 17 surface marker 2 antibody
    • Membrane component, chromosome 17, surface marker 2 (ovarian carcinoma antigen CA125) antibody
    • MIG 19 antibody
    • MIG19 antibody
    • Migration inducing protein 19 antibody
    • NBR 1 antibody
    • Nbr1 antibody
    • NBR1, autophagy cargo receptor antibody
    • NBR1_HUMAN antibody
    • Neighbor of BRCA1 gene 1 antibody
    • Neighbor of BRCA1 gene 1 protein antibody
    • Next to BRCA1 gene 1 protein antibody
    • Ovarian carcinoma antigen CA125 antibody
    • Protein 1A1-3B antibody
    see all

Images

  • Anti-NBR1 antibody (ab126175) at 1/1000 dilution + Jurkat whole cell lysate at 30 µg

    Predicted band size : 107 kDa
  • ab126175, at 1/250 dilution, staining NBR1 in paraffin-embedded Human Breast cancer tissue by Immunohistochemistry.

References

ab126175 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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