Overview

  • Product name
    NCH 51
  • Description
    Novel HDAC inhibitor
  • Alternative names
    • PTACH
  • Biological description
    Novel HDAC inhibitor (IC50 values are 32, 48 and 41 nM at HDAC4, HDAC1 and HDAC6, respectively). Induces apoptosis and inhibits cell growth of various malignant cells and tumor cells lines (EC50 = 3.8 μM). Also reactivates latent HIV-1 gene expression.
  • Purity
    > 99%

Properties

  • Chemical name
    2-Methylpropanethioic acid S-[7-oxo-7-[(4-phenyl-2-thiazolyl)amino]heptyl] ester
  • Molecular weight
    390.56
  • Chemical structure
    Chemical Structure
  • Molecular formula
    C20H26N2O2S2
  • CAS Number
    848354-66-5
  • PubChem identifier
    11395181
  • Storage instructions
    Store at +4°C. The product can be stored for up to 12 months.
  • Solubility overview
    Soluble in DMSO to 100 mM and in ethanol to 25 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES
    O=C(Nc1nc(cs1)c2ccccc2)CCCCCCSC(=O)C(C)C
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:
  • Victoriano AF  et al. Novel histone deacetylase inhibitor NCH-51 activates latent HIV-1 gene expression. FEBS Lett 585:1103-11 (2011). Read more (PubMed: 21402072) »
  • Sanda T  et al. Proteome analyses of the growth inhibitory effects of NCH-51, a novel histone deacetylase inhibitor, on lymphoid malignant cells. Leukemia 21:2344-53 (2007). Read more (PubMed: 17690692) »
  • Suzuki T  et al. Novel inhibitors of human histone deacetylases: design, synthesis, enzyme inhibition, and cancer cell growth inhibition of SAHA-based non-hydroxamates. J Med Chem 48:1019-32 (2005). Read more (PubMed: 15715470) »

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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