Overview

  • Product nameAnti-Nck antibody
    See all Nck primary antibodies
  • Description
    Rabbit polyclonal to Nck
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide conjugated to KLH, corresponding to a region between N terminal amino acids 62-92 of Human Nck (NP_001177725.1, NP_006144.1).

  • Positive control
    • K562 cell line lysates.

Properties

Associated products

Applications

Our Abpromise guarantee covers the use of ab116544 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/100 - 1/500. Predicted molecular weight: 43 kDa.

Target

  • FunctionAdapter protein which associates with tyrosine-phosphorylated growth factor receptors or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in the DNA damage response, not in the detection of the damage by ATM/ATR, but for efficient activation of downstream effectors, such as that of CHEK2.
  • Sequence similaritiesContains 1 SH2 domain.
    Contains 3 SH3 domains.
  • Post-translational
    modifications
    Phosphorylated on Ser and Tyr residues.
  • Cellular localizationCytoplasm. Endoplasmic reticulum. Nucleus. Mostly cytoplasmic, but shuttles between the cytoplasm and the nucleus. Import into the nucleus requires the interaction with SOCS7. Predominantly nuclear following genotoxic stresses, such as UV irradiation, hydroxyurea or mitomycin C treatments.
  • Information by UniProt
  • Database links
  • Alternative names
    • Cytoplasmic protein NCK1 antibody
    • Melanoma Nck protein antibody
    • MGC12668 antibody
    • NCK 1 antibody
    • NCK adaptor protein 1 antibody
    • NCK alpha antibody
    • NCK antibody
    • NCK tyrosine kinase antibody
    • Nck-1 antibody
    • NCK1 antibody
    • NCK1_HUMAN antibody
    • NCKalpha antibody
    • Non catalytic region of tyrosine kinase antibody
    • SH2/SH3 adaptor protein NCK alpha antibody
    • SH2/SH3 adaptor protein NCK-alpha antibody
    see all

Anti-Nck antibody images

  • Anti-Nck antibody (ab116544) at 1/100 dilution + K562 cell line lysates at 35 µg

    Predicted band size : 43 kDa

References for Anti-Nck antibody (ab116544)

ab116544 has not yet been referenced specifically in any publications.

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