The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
This peptide may be used for neutralization and control experiments with the polyclonal antibody that reacts with this product and rat Excanger (Na/Ca-k), catalog ab3507. Using a solution with equal weights per unit volume of peptide and corresponding antibody will yield a solution with a large molar excess of peptide that is able to competitively bind the antibody.
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Preparation and Storage
Stability and Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Na(+)/K(+)/Ca(2+) exchange protein 2
Na(+)/K(+)/Ca(2+)-exchange protein 2
Retinal cone Na Ca+K exchanger
Retinal cone Na-Ca+K exchanger
Sodium/potassium/calcium exchanger 2
Solute carrier family 24 (sodium/potassium/calcium exchanger) member 2
Solute carrier family 24 member 2
FunctionCritical component of the visual transduction cascade, controlling the calcium concentration of outer segments during light and darkness. Light causes a rapid lowering of cytosolic free calcium in the outer segment of both retinal rod and cone photoreceptors and the light-induced lowering of calcium is caused by extrusion via this protein which plays a key role in the process of light adaptation. Transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+).
Sequence similaritiesBelongs to the sodium/potassium/calcium exchanger family. SLC24A subfamily.