Anti-NCOR2/SMRT antibody (ab24551)
Key features and details
- Rabbit polyclonal to NCOR2/SMRT
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
Overview
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Product name
Anti-NCOR2/SMRT antibody
See all NCOR2/SMRT primary antibodies -
Description
Rabbit polyclonal to NCOR2/SMRT -
Host species
Rabbit -
Tested applications
Suitable for: WBmore details -
Species reactivity
Reacts with: Human -
Immunogen
Recombinant fragment corresponding to Human NCOR2/SMRT aa 1165-1363.
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
Concentration information loading...
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Purity
Whole antiserum -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
- Signal Transduction
- Signaling Pathway
- Nuclear Signaling
- Nuclear Hormone Receptors
- Co-activators/co-repressors
- Epigenetics and Nuclear Signaling
- Nuclear Signaling Pathways
- Nuclear Receptors
- Co-activators/co-repressors
- Epigenetics and Nuclear Signaling
- Chromatin Modifying Enzymes
- Acetylation
- HDACs
- Class II / Hda1 Class
Associated products
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ChIP Related Products
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Compatible Secondaries
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Isotype control
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab24551 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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WB | (1) |
1/1000. Detects a band of approximately 274 kDa (predicted molecular weight: 274 kDa).
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Notes |
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WB
1/1000. Detects a band of approximately 274 kDa (predicted molecular weight: 274 kDa). |
Target
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Function
Transcriptional corepressor of NR4A2/NURR1 and acts through histone deacetylases (HDACs) to keep promoters of NR4A2/NURR1 target genes in a repressed deacetylated state (By similarity). Mediates the transcriptional repression activity of some nuclear receptors by promoting chromatin condensation, thus preventing access of the basal transcription. Isoform 1 and isoform 5 have different affinities for different nuclear receptors. -
Tissue specificity
Ubiquitous. High levels of expression are detected in lung, spleen and brain. -
Sequence similarities
Belongs to the N-CoR nuclear receptor corepressors family.
Contains 2 SANT domains. -
Domain
The N-terminal region contains repression functions that are divided into three independent repression domains (RD1, RD2 and RD3). The C-terminal region contains the nuclear receptor-interacting domains that are divided in two separate interaction domains (ID1 and ID2).
The two interaction domains (ID) contain a conserved sequence referred to as the CORNR box. This motif is required and sufficient to permit binding to unligated TR and RARS. Sequences flanking the CORNR box determine nuclear hormone receptor specificity. -
Cellular localization
Nucleus. - Information by UniProt
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Database links
- Entrez Gene: 9612 Human
- Omim: 600848 Human
- SwissProt: Q9Y618 Human
- Unigene: 137510 Human
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Alternative names
- CTG 26 antibody
- CTG repeat protein 26 antibody
- CTG26 antibody
see all
Images
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Anti-NCOR2/SMRT antibody (ab24551) at 1/1000 dilution + HeLa nuclear extract
Predicted band size: 274 kDa
Observed band size: 270 kDa why is the actual band size different from the predicted?
Protocols
Datasheets and documents
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Datasheet download
References (29)
ab24551 has been referenced in 29 publications.
- Qin D et al. Lgr5+ cell fate regulation by coordination of metabolic nuclear receptors during liver repair. Theranostics 12:6130-6142 (2022). PubMed: 36168631
- Mori T et al. Low NCOR2 levels in multiple myeloma patients drive multidrug resistance via MYC upregulation. Blood Cancer J 11:194 (2021). PubMed: 34864816
- Long MD et al. Reduced NCOR2 expression accelerates androgen deprivation therapy failure in prostate cancer. Cell Rep 37:110109 (2021). PubMed: 34910907
- Tsoi H et al. Targeting the IL-6/STAT3 Signalling Cascade to Reverse Tamoxifen Resistance in Estrogen Receptor Positive Breast Cancer. Cancers (Basel) 13:N/A (2021). PubMed: 33806019
- Leung MH et al. A Splice Variant of NCOR2, BQ323636.1, Confers Chemoresistance in Breast Cancer by Altering the Activity of NRF2. Cancers (Basel) 12:N/A (2020). PubMed: 32110852