Overview

  • Product nameAnti-NDE1 antibody
    See all NDE1 primary antibodies
  • Description
    Mouse monoclonal to NDE1
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant full length protein, corresponding to amino acids 1-336 of Human NDE1

Properties

Applications

Our Abpromise guarantee covers the use of ab57430 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
  • Application notesWB: Use at a concentration of 1-5 µg/ml.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionRequired for centrosome duplication. Essential for the development of the cerebral cortex. May regulate the production of neurons by controlling the orientation of the mitotic spindle during division of cortical neuronal progenitors of the proliferative ventricular zone of the brain. Orientation of the division plane perpendicular to the layers of the cortex gives rise to two proliferative neuronal progenitors whereas parallel orientation of the division plane yields one proliferative neuronal progenitor and a post-mitotic neuron. A premature shift towards a neuronal fate within the progenitor population may result in an overall reduction in the final number of neurons and an increase in the number of neurons in the deeper layers of the cortex (By similarity). Required for formation and function of the mitotic spindle.
    • Sequence similaritiesBelongs to the nudE family.
    • Post-translational
      modifications
      Phosphorylated in mitosis.
    • Cellular localizationCytoplasm > cytoskeleton. Cytoplasm > cytoskeleton > centrosome. Chromosome > centromere > kinetochore. Cytoplasm > cytoskeleton > spindle. Cleavage furrow. Localizes to the interphase centrosome and to the mitotic spindle. Concentrates at the plus ends of microtubules coincident with kinetochores in metaphase and anaphase in a CENPF-dependent manner. Also localizes to the cleavage furrow during cytokinesis.
    • Information by UniProt
    • Database links
    • Alternative names
      • FLJ20101 antibody
      • HOM TES 87 antibody
      • LIS1 interacting protein NUDE1 rat homolog antibody
      • LIS1 interacting protein NUDE1 antibody
      • LIS4 antibody
      • NDE 1 antibody
      • NDE1 antibody
      • NDE1_HUMAN antibody
      • Nuclear distribution gene E homolog 1 antibody
      • Nuclear distribution protein nudE homolog 1 antibody
      • NUDE 1 antibody
      • NudE antibody
      • NudE nuclear distribution gene E homolog 1 (A. nidulans) antibody
      • NudE nuclear distribution gene E homolog 1 antibody
      • NUDE1 antibody
      see all

    Anti-NDE1 antibody images



    • Predicted band size : 38 kDa
      NDE1 antibody (ab57430) at 1ug/lane + HeLa cell lysate at 25ug/lane.

    References for Anti-NDE1 antibody (ab57430)

    This product has been referenced in:
    • Bradshaw NJ  et al. NDE1 and NDEL1: multimerisation, alternate splicing and DISC1 interaction. Neurosci Lett 449:228-33 (2009). WB . Read more (PubMed: 19000741) »
    • Brophy TM  et al. RN181, a novel ubiquitin E3 ligase that interacts with the KVGFFKR motif of platelet integrin alpha(IIb)beta3. Biochem Biophys Res Commun 369:1088-93 (2008). WB ; Human . Read more (PubMed: 18331836) »

    See all 2 Publications for this product

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"