Overview

  • Product nameAnti-NDE1 antibody
    See all NDE1 primary antibodies
  • Description
    Rabbit polyclonal to NDE1
  • Tested applicationsSuitable for: WBmore details
    Unsuitable for: IP
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Chimpanzee, Rhesus monkey, Gorilla, Orangutan
  • Immunogen

    A region between residues 50 and 100 of human NDE1 (NP_060138.1).

  • Positive control
    • HeLa whole cell lysate

Properties

Associated products

Applications

Our Abpromise guarantee covers the use of ab86075 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/2000 - 1/10000. Predicted molecular weight: 39 kDa.
  • Application notesIs unsuitable for IP.
  • Target

    • FunctionRequired for centrosome duplication. Essential for the development of the cerebral cortex. May regulate the production of neurons by controlling the orientation of the mitotic spindle during division of cortical neuronal progenitors of the proliferative ventricular zone of the brain. Orientation of the division plane perpendicular to the layers of the cortex gives rise to two proliferative neuronal progenitors whereas parallel orientation of the division plane yields one proliferative neuronal progenitor and a post-mitotic neuron. A premature shift towards a neuronal fate within the progenitor population may result in an overall reduction in the final number of neurons and an increase in the number of neurons in the deeper layers of the cortex (By similarity). Required for formation and function of the mitotic spindle.
    • Sequence similaritiesBelongs to the nudE family.
    • Post-translational
      modifications
      Phosphorylated in mitosis.
    • Cellular localizationCytoplasm > cytoskeleton. Cytoplasm > cytoskeleton > centrosome. Chromosome > centromere > kinetochore. Cytoplasm > cytoskeleton > spindle. Cleavage furrow. Localizes to the interphase centrosome and to the mitotic spindle. Concentrates at the plus ends of microtubules coincident with kinetochores in metaphase and anaphase in a CENPF-dependent manner. Also localizes to the cleavage furrow during cytokinesis.
    • Information by UniProt
    • Database links
    • Alternative names
      • FLJ20101 antibody
      • HOM TES 87 antibody
      • LIS1 interacting protein NUDE1 rat homolog antibody
      • LIS1 interacting protein NUDE1 antibody
      • LIS4 antibody
      • NDE 1 antibody
      • NDE1 antibody
      • NDE1_HUMAN antibody
      • Nuclear distribution gene E homolog 1 antibody
      • Nuclear distribution protein nudE homolog 1 antibody
      • NUDE 1 antibody
      • NudE antibody
      • NudE nuclear distribution gene E homolog 1 (A. nidulans) antibody
      • NudE nuclear distribution gene E homolog 1 antibody
      • NUDE1 antibody
      see all

    Anti-NDE1 antibody images

    • All lanes : Anti-NDE1 antibody (ab86075) at 0.04 µg/ml

      Lane 1 : HeLa whole cell lysate at 50 µg
      Lane 2 : HeLa whole cell lysate at 15 µg
      Lane 3 : HeLa whole cell lysate at 5 µg

      Developed using the ECL technique

      Predicted band size : 39 kDa


      Exposure time : 3 minutes

    References for Anti-NDE1 antibody (ab86075)

    ab86075 has not yet been referenced specifically in any publications.

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