Overview

  • Product nameAnti-NDP antibody
    See all NDP primary antibodies
  • Description
    Rabbit polyclonal to NDP
  • Tested applicationsSuitable for: WB, ICCmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    An 18 amino acid synthetic peptide from near the N-terminus of Human NDP (NP_000257).

  • Positive control
    • Jurkat cell lysate; Jurkat cells

Properties

Applications

Our Abpromise guarantee covers the use of ab106381 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 15 kDa.
ICC Use a concentration of 5 µg/ml.

Target

  • FunctionActivates the canonical Wnt signaling pathway through FZD4 and LRP5 coreceptor. Plays a central role in retinal vascularization by acting as a ligand for FZD4 that signals via stabilizing beta-catenin (CTNNB1) and activating LEF/TCF-mediated transcriptional programs. Acts in concert with TSPAN12 to activate FZD4 independently of the Wnt-dependent activation of FZD4, suggesting the existence of a Wnt-independent signaling that also promote accumulation the beta-catenin (CTNNB1). May be involved in a pathway that regulates neural cell differentiation and proliferation. Possible role in neuroectodermal cell-cell interaction.
  • Tissue specificityExpressed in the outer nuclear, inner nuclear and ganglion cell layers of the retina, and in fetal and adult brain.
  • Involvement in diseaseDefects in NDP are the cause of Norrie disease (ND) [MIM:310600]; also known as atrophia bulborum hereditaria or Episkopi blindness. ND is a recessive disorder characterized by very early childhood blindness due to degenerative and proliferative changes of the neuroretina. Approximately 50% of patients show some form of progressive mental disorder, often with psychotic features, and about one-third of patients develop sensorineural deafness in the second decade. In addition, some patients have more complex phenotypes, including growth failure and seizure.
    Defects in NDP are the cause of vitreoretinopathy exudative type 2 (EVR2) [MIM:305390]. EVR2 is a disorder of the retinal vasculature characterized by an abrupt cessation of growth of peripheral capillaries, leading to an avascular peripheral retina. This may lead to compensatory retinal neovascularization, which is thought to be induced by hypoxia from the initial avascular insult. New vessels are prone to leakage and rupture causing exudates and bleeding, followed by scarring, retinal detachment and blindness. Clinical features can be highly variable, even within the same family. Patients with mild forms of the disease are asymptomatic, and their only disease related abnormality is an arc of avascular retina in the extreme temporal periphery.
  • Sequence similaritiesContains 1 CTCK (C-terminal cystine knot-like) domain.
  • Cellular localizationSecreted.
  • Information by UniProt
  • Database links
  • Alternative names
    • EVR2 antibody
    • Exudative vitreoretinopathy 2 (X linked) antibody
    • FEVR antibody
    • ND antibody
    • NDP antibody
    • NDP_HUMAN antibody
    • Norrie disease (pseudoglioma) antibody
    • Norrie disease protein antibody
    • Norrin antibody
    • Norrin precursor antibody
    • X linked exudative vitreoretinopathy 2 protein antibody
    • X-linked exudative vitreoretinopathy 2 protein antibody
    see all

Anti-NDP antibody images

  • Lane 1 : Anti-NDP antibody (ab106381) at 1 µg/ml
    Lane 2 : Anti-NDP antibody (ab106381) at 2 µg/ml

    Lane 1 : Jurkat cell lysate
    Lane 2 : Jurkat cell lysate

    Lysates/proteins at 15 µg per lane.


    Predicted band size : 15 kDa
  • ab106381, at 5 µg/ml, staining NDP in Jurkat cells by Immunocytochemistry.

References for Anti-NDP antibody (ab106381)

ab106381 has not yet been referenced specifically in any publications.

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