FunctionAccessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Tissue specificityExpressed in all tissues examined with highest levels in heart, skeletal muscle and brain.
Sequence similaritiesBelongs to the complex I NDUFA5 subunit family.