Overview

  • Product name
  • Description
    Goat polyclonal to NDUFS8
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Mouse, Rat, Human
    Predicted to work with: Cow, Dog, Zebrafish
  • Immunogen

    Synthetic peptide:

    EAEIAANIQAD

    by a Cysteine residue linker, corresponding to internal sequence amino acids 196-206 of Human NDUFS8 (NP_002487.1.).

  • Positive control
    • Mouse heart lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab106800 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 0.1 - 0.3 µg/ml. Predicted molecular weight: 24 kDa.

Target

  • Function
    Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). May donate electrons to ubiquinone.
  • Involvement in disease
    Defects in NDUFS8 are a cause of Leigh syndrome (LS) [MIM:256000]. LS is a severe neurological disorder characterized by bilaterally symmetrical necrotic lesions in subcortical brain regions.
  • Sequence similarities
    Belongs to the complex I 23 kDa subunit family.
    Contains 2 4Fe-4S ferredoxin-type domains.
  • Cellular localization
    Mitochondrion.
  • Information by UniProt
  • Database links
  • Alternative names
    • CI 23kD antibody
    • CI-23kD antibody
    • Complex I 23kD antibody
    • Complex I-23kD antibody
    • EC 1.6.5.3 antibody
    • EC 1.6.99.3 antibody
    • Human mitochondrial NADH dehydrogenase ubiquinone Fe S protein 8 antibody
    • NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial antibody
    • NADH ubiquinone oxidoreductase 23 kDa subunit antibody
    • NADH-ubiquinone oxidoreductase 23 kDa subunit antibody
    • NDUFS8 antibody
    • NDUS8_HUMAN antibody
    • TYKY antibody
    • TYKY subunit antibody
    • Ubiquinoneiron sulfur protein 8, mitochondrial precursor antibody
    see all

Images

  • Anti-NDUFS8 antibody (ab106800) at 0.1 µg/ml + Mouse heart lysate (RIPA buffer) at 35 µg/ml
    Developed using the ECL technique

    Predicted band size : 24 kDa
    Observed band size : 25 kDa (why is the actual band size different from the predicted?)

References

ab106800 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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