Fast track antibodies constitute a diverse group of products that have been released to accelerate your research, but are not yet fully characterized. They have all been affinity purified and show high titre values against the immunizing peptide (by ELISA).
Use at an assay dependent dilution. Predicted molecular weight: 116 kDa. Preliminary experiments gave an approximate 30 kDa band in Human brain (frontal cortex) lysates, but not in Human, Mouse and Rat heart lysates after 1 µg/ml antibody staining. This protein has a calculated MW of 31.2 kDa according to NP_998734.1. The 30 kDa band was successfully blocked by incubation with the immunizing peptide.
RelevanceNebulette binds to actin and plays an important role in Z-disk assembly. It is a cardiac homolog of nebulin and its expression is abundant in cardiac muscle. Nebulette defects are assocated with non-familial idiopathic cardiacmyopathy