Overview

  • Product name
    Necrostatin-1, inactive control
  • Description
    Cell-permeable N-demethylated thiohydantoin analog of Necrostatin-1 (ab141053) without antinecroptotic properties
  • Alternative names
    • 5-((1H-indol-3-yl)methyl)-2-thioxoimidazolidin-4-one
    • 5-(Indol-3-ylmethyl)-2-thiohydantoin
    • Nec-1i
  • Biological description

    Cell-permeable N-demethylated thiohydantoin analog of Necrostatin-1 (Nec-1) (ab141053) without antinecroptotic properties; serves as an inactive control.

  • Purity
    > 95%
  • General notes

    This inactive inhibitor of necrosis should not be used in high concentration.

Properties

  • Chemical name
    5-(Indol-3-ylmethyl)-2-thiohydantoin
  • Molecular weight
    245.30
  • Chemical structure
    Chemical Structure
  • Molecular formula
    C12H11N3OS
  • CAS Number
    64419-92-7
  • Storage instructions
    Store at +4°C. The product can be stored for up to 12 months.
  • Solubility overview
    Soluble in DMSO
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • Source

    Synthetic

References

This product has been referenced in:
  • Vandenabeele P  et al. Necrostatin-1 blocks both RIPK1 and IDO: consequences for the study of cell death in experimental disease models. Cell Death Differ 20:185-7 (2013). Read more (PubMed: 23197293) »
  • Linkermann A  et al. The RIP1-kinase inhibitor necrostatin-1 prevents osmotic nephrosis and contrast-induced AKI in mice. J Am Soc Nephrol 24:1545-57 (2013). Read more (PubMed: 23833261) »
  • Takahashi N  et al. Necrostatin-1 analogues: critical issues on the specificity, activity and in vivo use in experimental disease models. Cell Death Dis 3:e437 (2012). Read more (PubMed: 23190609) »
  • Rosenbaum DM  et al. Necroptosis, a novel form of caspase-independent cell death, contributes to neuronal damage in a retinal ischemia-reperfusion injury model. J Neurosci Res 88:1569-76 (2010). Read more (PubMed: 20025059) »
  • Smith CC  et al. Necrostatin: a potentially novel cardioprotective agent? Cardiovasc Drugs Ther 21:227-33 (2007). Read more (PubMed: 17665295) »

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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