Cell-permeable N-demethylated thiohydantoin analog of Necrostatin-1 (Nec-1) (ab141053) without antinecroptotic properties; serves as an inactive control.
This inactive inhibitor of necrosis should not be used in high concentration.
Store at +4°C. The product can be stored for up to 12 months.
Soluble in DMSO
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Vandenabeele P et al. Necrostatin-1 blocks both RIPK1 and IDO: consequences for the study of cell death in experimental disease models. Cell Death Differ20:185-7 (2013).
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Linkermann A et al. The RIP1-kinase inhibitor necrostatin-1 prevents osmotic nephrosis and contrast-induced AKI in mice. J Am Soc Nephrol24:1545-57 (2013).
Read more (PubMed: 23833261) »
Takahashi N et al. Necrostatin-1 analogues: critical issues on the specificity, activity and in vivo use in experimental disease models. Cell Death Dis3:e437 (2012).
Read more (PubMed: 23190609) »
Rosenbaum DM et al. Necroptosis, a novel form of caspase-independent cell death, contributes to neuronal damage in a retinal ischemia-reperfusion injury model. J Neurosci Res88:1569-76 (2010).
Read more (PubMed: 20025059) »