Overview

  • Product name
  • Description
    Mouse polyclonal to Nectin 3
  • Host species
    Mouse
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse
  • Immunogen

    Full length protein, corresponding to amino acids 1-366 of Human Nectin 3 (AAH67808.1).

  • Positive control
    • Nectin 3 transfected 293T cell lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab168266 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 40 kDa.

Target

  • Function
    Plays a role in cell-cell adhesion through heterophilic trans-interactions with nectin-like proteins or nectins, such as trans-interaction with PVRL2/nectin-2 at Sertoli-spermatid junctions. Trans-interaction with PVR induces activation of CDC42 and RAC small G proteins through common signaling molecules such as SRC and RAP1. Also involved in the formation of cell-cell junctions, including adherens junctions and synapses. Induces endocytosis-mediated down-regulation of PVR from the cell surface, resulting in reduction of cell movement and proliferation. Plays a role in the morphology of the ciliary body.
  • Tissue specificity
    Predominantly expressed in testis and placenta as well as in many cell lines, including epithelial cell lines.
  • Sequence similarities
    Belongs to the nectin family.
    Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
    Contains 1 Ig-like V-type (immunoglobulin-like) domain.
  • Cellular localization
    Cell membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • CD113 antibody
    • CDw113 antibody
    • DKFZP566B0846 antibody
    • FLJ90624 antibody
    • Nectin-3 antibody
    • Nectin3 antibody
    • Poliovirus receptor related 3 antibody
    • Poliovirus receptor related protein 3 antibody
    • Poliovirus receptor-like 3 antibody
    • Poliovirus receptor-related protein 3 antibody
    • PPR3 antibody
    • PRR3 antibody
    • Pvrl3 antibody
    • PVRL3_HUMAN antibody
    • PVRR3 antibody
    see all

Images

  • All lanes : Anti-Nectin 3 antibody (ab168266) at 1 µg/ml

    Lane 1 : Nectin 3 transfected 293T cell lysate
    Lane 2 : Non transfected 293T cell lysate

    Lysates/proteins at 15 µl per lane.

    Secondary
    All lanes : Goat Anti-Mouse IgG (H&L)-HRP at 1/2500 dilution

    Developed using the ECL technique.

    Predicted band size: 40 kDa

References

ab168266 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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