Overview

  • Product name
  • Description
    Rabbit polyclonal to Nectin 3
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Rabbit, Horse, Guinea pig, Cow, Cat, Dog, Pig
  • Immunogen

    Synthetic peptide corresponding to a region within N terminal amino acids 143-192 (SGKYICKAVT FPLGNAQSST TVTVLVEPTV SLIKGPDSLI DGGNETVAAI) of Human Nectin 3 (NP_056295).

  • Positive control
    • HT1080 cell lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab98342 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 61 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

Target

  • Function
    Plays a role in cell-cell adhesion through heterophilic trans-interactions with nectin-like proteins or nectins, such as trans-interaction with PVRL2/nectin-2 at Sertoli-spermatid junctions. Trans-interaction with PVR induces activation of CDC42 and RAC small G proteins through common signaling molecules such as SRC and RAP1. Also involved in the formation of cell-cell junctions, including adherens junctions and synapses. Induces endocytosis-mediated down-regulation of PVR from the cell surface, resulting in reduction of cell movement and proliferation. Plays a role in the morphology of the ciliary body.
  • Tissue specificity
    Predominantly expressed in testis and placenta as well as in many cell lines, including epithelial cell lines.
  • Sequence similarities
    Belongs to the nectin family.
    Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
    Contains 1 Ig-like V-type (immunoglobulin-like) domain.
  • Cellular localization
    Cell membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • CD113 antibody
    • CDw113 antibody
    • DKFZP566B0846 antibody
    • FLJ90624 antibody
    • Nectin-3 antibody
    • Nectin3 antibody
    • Poliovirus receptor related 3 antibody
    • Poliovirus receptor related protein 3 antibody
    • Poliovirus receptor-like 3 antibody
    • Poliovirus receptor-related protein 3 antibody
    • PPR3 antibody
    • PRR3 antibody
    • Pvrl3 antibody
    • PVRL3_HUMAN antibody
    • PVRR3 antibody
    see all

Images

  • Anti-Nectin 3 antibody (ab98342) at 1 µg/ml + HT1080 cell lysate at 10 µg

    Predicted band size : 61 kDa

References

ab98342 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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