Anti-NEDL2 antibody (ab92711)
Key features and details
- Rabbit polyclonal to NEDL2
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
Overview
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Product name
Anti-NEDL2 antibody
See all NEDL2 primary antibodies -
Description
Rabbit polyclonal to NEDL2 -
Host species
Rabbit -
Tested applications
Suitable for: WBmore details -
Species reactivity
Reacts with: Human -
Immunogen
Synthetic peptide derived from an internal region of Human NEDL2.
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles. -
Storage buffer
pH: 7.40
Preservative: 0.02% Sodium azide
Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride
Without Mg2+ and Ca2+ -
Concentration information loading...
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Purity
Immunogen affinity purified -
Purification notes
The antibody was affinity purified from rabbit antiserum by affinity chromatography using epitope specific immunogen. -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab92711 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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WB |
1/500 - 1/1000. Predicted molecular weight: 176 kDa.
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Notes |
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WB
1/500 - 1/1000. Predicted molecular weight: 176 kDa. |
Target
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Function
E3 ubiquitin-protein ligase that mediates ubiquitination of TP73. Acts to stabilize TP73 and enhance activation of transcription by TP73. -
Tissue specificity
Predominantly expressed in adult brain, lung and heart. -
Pathway
Protein modification; protein ubiquitination. -
Sequence similarities
Contains 1 C2 domain.
Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain.
Contains 2 WW domains. -
Cellular localization
Cytoplasm. - Information by UniProt
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Database links
- Entrez Gene: 57520 Human
- SwissProt: Q9P2P5 Human
- Unigene: 654742 Human
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Alternative names
- C2 and WW domain-containing protein 2 antibody
- E3 ubiquitin protein ligase HECW2 antibody
- E3 ubiquitin-protein ligase HECW2 antibody
see all
Images
Datasheets and documents
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SDS download
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Datasheet download
References (2)
ab92711 has been referenced in 2 publications.
- Mao J et al. NEDD4-like ubiquitin ligase 2 protein (NEDL2) in porcine spermatozoa, oocytes, and preimplantation embryos and its role in oocyte fertilization†. Biol Reprod 104:117-129 (2021). PubMed: 33030211
- Qiu X et al. NEDL2 regulates enteric nervous system and kidney development in its Nedd8 ligase activity-dependent manner. Oncotarget 7:31440-53 (2016). PubMed: 27119228