Overview

  • Product name
    Nefopam hydrochloride
  • Description
    Centrally-acting, non-opioid analgesic drug
  • Alternative names
    • 3,4,5,6-Tetrahydro-5-methyl-1-phenyl-1H-2,5-benzoxazocine hydrochloride
    • Acupan
  • Biological description

    Centrally-acting, non-opiod analgesic drug of the benzoxazocine chemical class. Blocks voltage-sensitive sodium channels and modulates glutamatergic transmission in rodents. Inhibits serotonin, noradrenaline and dopamine reuptake.

  • Purity
    > 99%

Properties

  • Chemical name
    5-Methyl-1-phenyl-1,3,4,6-tetrahydro-2,5-benzoxazocine hydrochloride
  • Molecular weight
    289.80
  • Chemical structure
    Chemical Structure
  • Molecular formula
    C17H19NO.HCl
  • CAS Number
    23327-57-3
  • Storage instructions
    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview
    Soluble in DMSO to 3 mM and in water to 50 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • Source

    Synthetic

References

This product has been referenced in:
  • Evans MS  et al. Nefopam for the prevention of postoperative pain: quantitative systematic review. Br J Anaesth 101:610-7 (2008). Read more (PubMed: 18796441) »
  • Verleye M  et al. Nefopam blocks voltage-sensitive sodium channels and modulates glutamatergic transmission in rodents. Brain Res 1013:249-55 (2004). Read more (PubMed: 15193535) »
  • Fuller RW & Snoddy HD Evaluation of nefopam as a monoamine uptake inhibitor in vivo in mice. Neuropharmacology 32:995-9 (1993). Read more (PubMed: 7507578) »
  • Piercey MF & Schroeder LA Spinal and Supraspinal sites for morphine and nefopam analgesia in the mouse. Eur J Pharmacol 74:135-40 (1981). Read more (PubMed: 6276187) »
  • Gassel MM  et al. Controlled clinical trial of oral and parenteral nefopam hydrochloride. A novel and potent analgesic drug. J Clin Pharmacol 16:34-41 (1976). Read more (PubMed: 1107359) »

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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