FunctionInvolved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Has DNA glycosylase activity towards 5-hydroxyuracil and other oxidized derivatives of cytosine with a preference for mismatched double stranded DNA (DNA bubbles). Has low or no DNA glycosylase activity towards thymine glycol, 2-hydroxyadenine, hypoxanthine and 8-oxoguanine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
Tissue specificityDetected in testis, skeletal muscle, heart, brain, placenta, lung, pancreas, kidney and liver.
Sequence similaritiesBelongs to the FPG family. Contains 1 FPG-type zinc finger.
DomainThe zinc-finger domain is important for DNA binding.