Overview

  • Product nameAnti-NEIL2 antibody
    See all NEIL2 primary antibodies
  • Description
    Rabbit polyclonal to NEIL2
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide conjugated to KLH, corresponding to a sequence between N terminal amino acids 66-96 of Human NEIL2 (NP_001129220.1, NP_001129218.1, NP_659480.1).

  • Positive control
    • HepG2 cell line lysates

Properties

  • FormLiquid
  • Storage instructionsShipped at 4°C. Store at 4°C (up to 6 months). Store at -20°C long term.
  • Storage bufferPreservative: 0.09% Sodium azide
    Constituent: 99% PBS
  • Concentration information loading...
  • PurityImmunogen affinity purified
  • Purification notesab124106 is purified through a protein A column, followed by peptide affinity purification.
  • ClonalityPolyclonal
  • IsotypeIgG
  • Research areas

Associated products

Applications

Our Abpromise guarantee covers the use of ab124106 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/100 - 1/500. Predicted molecular weight: 37 kDa.

Target

  • FunctionInvolved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Has DNA glycosylase activity towards 5-hydroxyuracil and other oxidized derivatives of cytosine with a preference for mismatched double stranded DNA (DNA bubbles). Has low or no DNA glycosylase activity towards thymine glycol, 2-hydroxyadenine, hypoxanthine and 8-oxoguanine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
  • Tissue specificityDetected in testis, skeletal muscle, heart, brain, placenta, lung, pancreas, kidney and liver.
  • Sequence similaritiesBelongs to the FPG family.
    Contains 1 FPG-type zinc finger.
  • DomainThe zinc-finger domain is important for DNA binding.
  • Cellular localizationNucleus.
  • Information by UniProt
  • Database links
  • Alternative names
    • DNA glycosylase/AP lyase Neil2 antibody
    • DNA-(apurinic or apyrimidinic site) lyase Neil2 antibody
    • Endonuclease 8-like 2 antibody
    • Endonuclease VIII-like 2 antibody
    • NEH2 antibody
    • Nei endonuclease VIII like 2 (E. coli) antibody
    • Nei endonuclease VIII like 2 antibody
    • Nei homolog 2 antibody
    • Nei-like 2 antibody
    • Nei-like protein 2 antibody
    • NEI2 antibody
    • NEIL2 antibody
    • NEIL2_HUMAN antibody
    see all

Anti-NEIL2 antibody images

  • Anti-NEIL2 antibody (ab124106) at 1/100 dilution + HepG2 cell line lysates at 35 µg

    Predicted band size : 37 kDa

References for Anti-NEIL2 antibody (ab124106)

ab124106 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"