Overview

  • Product nameAnti-NELF antibody
    See all NELF primary antibodies
  • Description
    Rabbit polyclonal to NELF
  • SpecificityNELF recognises both the 263 aa and 528 aa isoform.
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Rabbit, Horse, Guinea pig, Cow, Cat, Dog
  • Immunogen

    A region within synthetic peptide: SDPTPMKADT SHDSRDSSDL QSSHCTLDEA FEDLDWDTEK GLEAVACDTE, corresponding to internal sequence amino acids 289-338 of Human NELF

  • Positive control
    • HepG2 cell lysate

Properties

  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • Storage bufferPreservative: None
    Constituents: 2% Sucrose, PBS
  • Concentration information loading...
  • PurityProtein A purified
  • ClonalityPolyclonal
  • IsotypeIgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab58752 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 5 µg/ml. Detects a band of approximately 29 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

Target

  • FunctionCouples NMDA receptor signaling to the nucleus. Influences outgrowth of olfactory axons and migration of LHRH neurons.
  • Tissue specificityHighly expressed in adult and fetal brain, testis and kidney.
  • Involvement in diseaseDefects in NELF may be associated with idiopathic hypogonadotropic hypogonadism (IHH) [MIM:146110]. IHH is defined as a deficiency of the pituitary secretion of follicle-stimulating hormone and luteinizing hormone, which results in the impairment of pubertal maturation and of reproductive function.
  • Cellular localizationCell membrane. Nucleus. Found on the outside of the LHRH cell membrane and axons projecting from the olfactory pit and epithelium. Myristoylation is a prerequisite for extranuclear localization.
  • Information by UniProt
  • Database links
  • Alternative names
    • Nasal embryonic LHRH factor antibody
    • Nasal embryonic luteinizing hormone releasing hormone factor antibody
    • Nasal embryonic luteinizing hormone-releasing hormone factor antibody
    • Nelf antibody
    • NELF_HUMAN antibody
    see all

Anti-NELF antibody images

References for Anti-NELF antibody (ab58752)

ab58752 has not yet been referenced specifically in any publications.

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