Anti-NELFe antibody (ab84986)

Overview

• Product nameAnti-NELFe antibody
  See all NELFe primary antibodies
• Description
  Rabbit polyclonal to NELFe
• Tested applicationsSuitable for: IHC-Pmore details
• Species reactivity
  Reacts with: Human
  Predicted to work with: Horse, Guinea pig, Cow, Dog, Pig, Chimpanzee, Rhesus monkey, Gorilla, Orangutan, Elephant
• Immunogen

  Synthetic peptide, corresponding to a region between residue 330 and 380 of human NELFe (NP_002895.3)

• Positive control
  • Human Breast Carcinoma, human Placenta

Properties

• FormLiquid
• Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
• Storage bufferPreservative: 0.09% Sodium Azide
  Constituents: 0.1% BSA, Tris buffered saline
• Concentration information loading...
• PurityImmunogen affinity purified
• ClonalityPolyclonal
• IsotypeIgG
• Research areas
  • Epigenetics and Nuclear Signaling
  • Transcription
  • Elongation factors

Associated products

• Compatible Secondaries
  • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
  • Goat Anti-Rabbit IgG H&L (HRP) (ab205718)
• Positive Controls
  • Placenta (human) normal tissue slides (ab4360)
  • Stomach tumor (human): adenocarcinoma (moderately differentiated) tissue slides (ab5116)
  • Stomach tumor (human): adenocarcinoma (well differentiated) tissue slides (ab5117)
  • Testis tumor (human): seminoma tissue slides (ab5129)

Applications

Target

• FunctionEssential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II. The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex.
• Tissue specificityWidely expressed. Expressed in heart, brain, lung, placenta, liver, skeletal muscle, kidney and pancreas.
• Sequence similaritiesBelongs to the RRM NELF-E family.
  Contains 1 RRM (RNA recognition motif) domain.
• DomainThe RRM domain interacts with RNA, and is essential for NELF complex function. It is however not required for the NELF complex formation.
• Post-translational
  modificationsSumoylated.
• Cellular localizationNucleus.

• Target information above from: UniProt accession P18615 The UniProt Consortium
  The Universal Protein Resource (UniProt) in 2010
  Nucleic Acids Res. 38:D142-D148 (2010) .

  Information by UniProt
• Database links
  • Entrez Gene: 7936 Human
  • Omim: 154040 Human
  • SwissProt: P18615 Human
  • Unigene: 423935 Human
• Alternative names
  • Major histocompatibility complex gene RD antibody
  • Negative elongation factor E antibody
  • Negative elongation factor polypeptide E antibody

  • NELF e antibody
  • NELF-E antibody
  • Nelfe antibody
  • NELFE_HUMAN antibody
  • Nuclear protein antibody
  • RD antibody
  • RD protein antibody
  • RD RNA binding protein antibody
  • RDP antibody
  • RNA-binding protein RD antibody

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