Overview

  • Product nameAnti-Nephrocystin 4 antibody
    See all Nephrocystin 4 primary antibodies
  • Description
    Rabbit polyclonal to Nephrocystin 4
  • Tested applicationsSuitable for: IHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide derived from an internal sequence from the Human Nephrocystin 4 protein (O75161).

  • Positive control
    • human colon carcinoma tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab111408 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/50 - 1/100. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Target

  • Tissue specificityExpressed in kidney, skeletal muscle, heart and liver, and to a lesser extent in brain and lung.
  • Involvement in diseaseDefects in NPHP4 are the cause of nephronophthisis type 4 (NPHP4) [MIM:606966]; also known as familial juvenile nephronophthisis 4. NPHP4 is an autosomal recessive inherited disease resulting in end-stage renal disease at age ranging between 6 and 35 years. It is a progressive tubulo-interstitial kidney disorder characterized by polydipsia, polyuria, anemia and growth retardation. The most prominent histological features are modifications of the tubules with thickening of the basement membrane, interstitial fibrosis and, in the advanced stages, medullary cysts.
    Defects in NPHP4 are the cause of Senior-Loken syndrome type 4 (SLSN4) [MIM:606996]. SLSN is a renal-retinal disorder characterized by progressive wasting of the filtering unit of the kidney, with or without medullary cystic renal disease, and progressive eye disease. Typically this disorder becomes apparent during the first year of life.
  • Sequence similaritiesBelongs to the NPHP4 family.
  • Cellular localizationCytoplasm > cytoskeleton > cilium basal body. Cytoplasm > cytoskeleton > centrosome.
  • Information by UniProt
  • Database links
  • Alternative names
    • KIAA0673 antibody
    • Nephrocystin-4 antibody
    • nephronophthisis 4 antibody
    • Nephroretinin antibody
    • NPHP4 antibody
    • NPHP4_HUMAN antibody
    • POC10 antibody
    • POC10 centriolar protein homolog antibody
    • SLSN4 antibody
    see all

Anti-Nephrocystin 4 antibody images

  • Immunohistochemistry analysis of paraffin-embedded human colon carcinoma tissue using anti Nephrocystin 4 antibody (ab111408). The picture on the right is treated with the synthesized peptide.

References for Anti-Nephrocystin 4 antibody (ab111408)

ab111408 has not yet been referenced specifically in any publications.

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