Overview

  • Product name
    Anti-Nephrocystin 4 antibody
    See all Nephrocystin 4 primary antibodies
  • Description
    Rabbit polyclonal to Nephrocystin 4
  • Host species
    Rabbit
  • Tested applications
    Suitable for: IHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide derived from internal sequence of Human Nephrocystin 4.

  • Positive control
    • Human kidney tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab167035 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P Use a concentration of 5 µg/ml.

Target

  • Tissue specificity
    Expressed in kidney, skeletal muscle, heart and liver, and to a lesser extent in brain and lung.
  • Involvement in disease
    Defects in NPHP4 are the cause of nephronophthisis type 4 (NPHP4) [MIM:606966]; also known as familial juvenile nephronophthisis 4. NPHP4 is an autosomal recessive inherited disease resulting in end-stage renal disease at age ranging between 6 and 35 years. It is a progressive tubulo-interstitial kidney disorder characterized by polydipsia, polyuria, anemia and growth retardation. The most prominent histological features are modifications of the tubules with thickening of the basement membrane, interstitial fibrosis and, in the advanced stages, medullary cysts.
    Defects in NPHP4 are the cause of Senior-Loken syndrome type 4 (SLSN4) [MIM:606996]. SLSN is a renal-retinal disorder characterized by progressive wasting of the filtering unit of the kidney, with or without medullary cystic renal disease, and progressive eye disease. Typically this disorder becomes apparent during the first year of life.
  • Sequence similarities
    Belongs to the NPHP4 family.
  • Cellular localization
    Cytoplasm > cytoskeleton > cilium basal body. Cytoplasm > cytoskeleton > centrosome.
  • Information by UniProt
  • Database links
  • Alternative names
    • KIAA0673 antibody
    • Nephrocystin-4 antibody
    • nephronophthisis 4 antibody
    • Nephroretinin antibody
    • NPHP4 antibody
    • NPHP4_HUMAN antibody
    • POC10 antibody
    • POC10 centriolar protein homolog antibody
    • SLSN4 antibody
    see all

Images

  • Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human kidney tissue labeling Nephrocystin 4 with ab167035 at 5 µg/ml.

References

ab167035 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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