This antibody gave a positive signal in both Human Kidney and Lung tissue lysates.
Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
Storage bufferpH: 7.40 Preservative: 0.02% Sodium azide Constituent: PBS Note: Batches of this product that have a concentration < 1mg/ml may have BSA added as a stabilising agent. If you would like information about the formulation of a specific lot, please contact our scientific support team who will be happy to help.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Use a concentration of 1 µg/ml. Detects a band of approximately 70 kDa (predicted molecular weight: 62 kDa).
FunctionFunctional ligand of integrin alpha-8/beta-1 in kidney development. Regulates the expression of GDNF with integrin alpha-8/beta-1 which is essential for kidney development. May also play a role in the development and function of various tissues, regulating cell adhesion, spreading and survival through the binding of several integrins.
Tissue specificityExpressed in kidney and lung and to a lower extent in brain, pregnant uterus, placenta, thyroid gland and blood vessels.
Sequence similaritiesBelongs to the nephronectin family. Contains 5 EGF-like domains. Contains 1 MAM domain.
Developmental stageExpressed in fetal kidney, cochlea, eye, heart and lung.
DomainThe MAM domain is required for localization at the cell surface.
Cellular localizationSecreted > extracellular space > extracellular matrix. Trapped on the cell surface or in the extracellular matrix.