Overview

  • Product nameAnti-Netrin 1 antibody
    See all Netrin 1 primary antibodies
  • Description
    Rabbit polyclonal to Netrin 1
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Mouse
    Predicted to work with: Rat, Chicken, Human, Xenopus laevis, Zebrafish
  • Immunogen

    Synthetic peptide:

    VQIHILKADKAG

    , corresponding to amino acids 497 - 508 of Mouse Netrin 1

  • Positive control
    • Mouse brain tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab26162 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use at an assay dependent dilution. Detects a band of approximately 67 kDa.

Target

  • FunctionNetrins control guidance of CNS commissural axons and peripheral motor axons. Its association with either DCC or some UNC5 receptors will lead to axon attraction or repulsion, respectively. It also serve as a survival factor via its association with its receptors which prevent the initiation of apoptosis. Involved in tumorigenesis by regulating apoptosis.
  • Tissue specificityWidely expressed in normal adult tissues with highest levels in heart, small intestine, colon, liver and prostate. Reduced expression in brain tumors and neuroblastomas.
  • Sequence similaritiesContains 3 laminin EGF-like domains.
    Contains 1 laminin N-terminal domain.
    Contains 1 NTR domain.
  • Cellular localizationSecreted > extracellular space > extracellular matrix.
  • Information by UniProt
  • Database links
  • Alternative names
    • epididymis tissue protein Li 131P antibody
    • NET1_HUMAN antibody
    • Netrin 1, mouse, homolog of antibody
    • Netrin 1-like antibody
    • Netrin-1 antibody
    • Netrin1 antibody
    • Ntn 1 antibody
    • NTN 1L antibody
    • NTN1 antibody
    • NTN1L antibody
    • Unc6 antibody
    see all

Anti-Netrin 1 antibody images

  • All lanes : Anti-Netrin 1 antibody (ab26162) at 1 µg/ml

    Lane 1 : Mouse brain extract (Embryonic day 14)
    Lane 2 : Mouse brain extract (Embryonic day 16)
    Lane 3 : Mouse brain extract (Post natal day 1)
    Lane 4 : Mouse brain extract (Adult)


    Observed band size : 67 kDa (why is the actual band size different from the predicted?)

References for Anti-Netrin 1 antibody (ab26162)

This product has been referenced in:
  • van Gils JM  et al. The neuroimmune guidance cue netrin-1 promotes atherosclerosis by inhibiting the emigration of macrophages from plaques. Nat Immunol 13:136-43 (2012). Read more (PubMed: 22231519) »
  • Foran E  et al. Motor neuron impairment mediated by a sumoylated fragment of the glial glutamate transporter EAAT2. Glia 59:1719-31 (2011). Mouse . Read more (PubMed: 21769946) »

See all 3 Publications for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"