Overview

  • Product name
  • Description
    Chicken polyclonal to Netrin 1
  • Tested applications
    Suitable for: IHC-P, IHC-Fr, ICC/IF, WBmore details
  • Species reactivity
    Reacts with: Mouse, Human
  • Immunogen

    Synthetic peptide corresponding to a region of the Netrin 1 gene product shared between the mouse (O09118, NCBI) and human (O95631, NCBI) gene products.

Properties

Applications

Our Abpromise guarantee covers the use of ab39370 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/100 - 1/200.
IHC-Fr 1/100 - 1/200.
ICC/IF 1/100 - 1/200.
WB 1/250 - 1/500. Predicted molecular weight: 68 kDa.

Target

  • Function
    Netrins control guidance of CNS commissural axons and peripheral motor axons. Its association with either DCC or some UNC5 receptors will lead to axon attraction or repulsion, respectively. It also serve as a survival factor via its association with its receptors which prevent the initiation of apoptosis. Involved in tumorigenesis by regulating apoptosis.
  • Tissue specificity
    Widely expressed in normal adult tissues with highest levels in heart, small intestine, colon, liver and prostate. Reduced expression in brain tumors and neuroblastomas.
  • Sequence similarities
    Contains 3 laminin EGF-like domains.
    Contains 1 laminin N-terminal domain.
    Contains 1 NTR domain.
  • Cellular localization
    Secreted > extracellular space > extracellular matrix.
  • Information by UniProt
  • Database links
  • Alternative names
    • epididymis tissue protein Li 131P antibody
    • NET1_HUMAN antibody
    • Netrin 1, mouse, homolog of antibody
    • Netrin 1-like antibody
    • Netrin-1 antibody
    • Netrin1 antibody
    • Ntn 1 antibody
    • NTN 1L antibody
    • NTN1 antibody
    • NTN1L antibody
    • Unc6 antibody
    see all

Anti-Netrin 1 antibody images

  • Dissociated cell cultures of an e13 mouse brain showing Netrin 1 (green staining) in neuronal precursor cells.

References for Anti-Netrin 1 antibody (ab39370)

This product has been referenced in:
  • Cayre M  et al. Netrin 1 contributes to vascular remodeling in the subventricular zone and promotes progenitor emigration after demyelination. Development 140:3107-17 (2013). Read more (PubMed: 23824572) »
  • Chen Q  et al. N-terminal horseshoe conformation of DCC is functionally required for axon guidance and might be shared by other neural receptors. J Cell Sci 126:186-95 (2013). Read more (PubMed: 23038776) »

See all 5 Publications for this product

Product Wall

Tal y como hemos quedado, he creado un código de descuento: XXXXXX para testar ab5794 en células de gato mediante ICC.

El código caduca el día 20-Marzo-2013.

Este código tiene un valor de €370...

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Thank you for contacting Abcam.

I have attached the Abcam protocols books that contains some good IHC-P protocols, which contains some good general starting protocols. Specifically for ab39370, we recommend a starting primary antibody concentr...

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Thank you for contacting us.



I am sorry to hear that you have been experiencing difficulties using this ab39370 anti-netrin1 antibody. Please find the protocols used for the ICC/IF results below.



1. Draw of cul...

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Thank you for your enquiry. I have contacted the originator of the product but unfortunately, the exact peptide sequence information is proprietary and cannot be released. However, I did confirm that it is a synthetic peptide corresponding to a...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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