Overview

  • Product nameAnti-Netrin 1 antibody
    See all Netrin 1 primary antibodies
  • Description
    Rabbit polyclonal to Netrin 1
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Mouse, Zebrafish
    Predicted to work with: Rat, Human, Pig, Xenopus laevis
  • Immunogen

    Synthetic peptide conjugated to KLH derived from within residues 100 - 200 of Mouse Netrin 1.

  • Positive control
    • This antibody gave a positive signal in Mouse Fetus (14 Day Old) Tissue Lysate.

Properties

Associated products

Applications

Our Abpromise guarantee covers the use of ab78854 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
  • Application notesWB: Use at a concentration of 1 µg/ml. Detects a band of approximately 70 kDa (predicted molecular weight: 68 kDa).
    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionNetrins control guidance of CNS commissural axons and peripheral motor axons. Its association with either DCC or some UNC5 receptors will lead to axon attraction or repulsion, respectively. It also serve as a survival factor via its association with its receptors which prevent the initiation of apoptosis. Involved in tumorigenesis by regulating apoptosis.
    • Tissue specificityWidely expressed in normal adult tissues with highest levels in heart, small intestine, colon, liver and prostate. Reduced expression in brain tumors and neuroblastomas.
    • Sequence similaritiesContains 3 laminin EGF-like domains.
      Contains 1 laminin N-terminal domain.
      Contains 1 NTR domain.
    • Cellular localizationSecreted > extracellular space > extracellular matrix.
    • Information by UniProt
    • Database links
    • Alternative names
      • epididymis tissue protein Li 131P antibody
      • NET1_HUMAN antibody
      • Netrin 1, mouse, homolog of antibody
      • Netrin 1-like antibody
      • Netrin-1 antibody
      • Netrin1 antibody
      • Ntn 1 antibody
      • NTN 1L antibody
      • NTN1 antibody
      • NTN1L antibody
      • Unc6 antibody
      see all

    Anti-Netrin 1 antibody images

    • Anti-Netrin 1 antibody (ab78854) at 1 µg/ml + Mouse Fetus (14 Day Old) Tissue Lysate at 10 µg

      Secondary
      Goat polyclonal to Rabbit IgG - H&L - Pre-Adsorbed (HRP) at 1/3000 dilution
      Developed using the ECL technique

      Performed under reducing conditions.

      Predicted band size : 68 kDa
      Observed band size : 72 kDa (why is the actual band size different from the predicted?)
      Additional bands at : 25 kDa. We are unsure as to the identity of these extra bands.

      Exposure time : 3 minutes

    References for Anti-Netrin 1 antibody (ab78854)

    This product has been referenced in:
    • Liao SJ  et al. Netrin-1 rescues neuron loss by attenuating secondary apoptosis in ipsilateral thalamic nucleus following focal cerebral infarction in hypertensive rats. Neuroscience 231:225-32 (2013). Read more (PubMed: 23232257) »

    See 1 Publication for this product

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"